INT340625

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.61
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Vegfa) cell proliferation (Vegfa) extracellular space (Vegfa)
growth (Vegfa) extracellular region (Vegfa) plasma membrane (Vegfa)
Anatomy Link Frequency
myocyte 1
Vegfa (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 103 97.82 Very High Very High Very High
cva 1 82.88 Quite High
Inflammation 22 66.40 Quite High
alcohol 4 5.00 Very Low Very Low Very Low
Pain management 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 6 98.76 Very High Very High Very High
Toxicity 43 96.96 Very High Very High Very High
Necrosis 15 96.68 Very High Very High Very High
Overdose 1 86.80 High High
Cv General 3 Under Development 1 82.88 Quite High
Heart Rate Under Development 1 78.56 Quite High
Cardiovascular Disorder Under Development 9 76.68 Quite High
Fibrosis 2 66.88 Quite High
INFLAMMATION 22 66.40 Quite High
Drug Induced Neurotoxicity 4 16.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that these toxicity pattern may be associated with paracetamol metabolite and free radical NAPQI, resulting in myocyte glutathione depletion, damage to the myocardium and breakdown of endothelium-derived vascular relaxing factor (EDRF), leading to functional coronary insufficiency [33] and myocyte coagulative necrosis which has been observed in our study and in previous ones [52].
Protein_catabolism (breakdown) of vascular relaxing factor in myocyte associated with necrosis, toxicity, paracetamol and cv unclassified under development
1) Confidence 0.05 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2965131 Disease Relevance 1.61 Pain Relevance 0.64

General Comments

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