INT340642

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Context Info
Confidence 0.62
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.26
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ccr2) signal transduction (Ccr2) plasma membrane (Ccr2)
signal transducer activity (Ccr2)
Anatomy Link Frequency
leukocytes 2
T cells 2
Ccr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 110 99.36 Very High Very High Very High
chemokine 35 94.36 High High
Multiple sclerosis 10 79.32 Quite High
imagery 15 56.08 Quite High
Spinal cord 10 44.16 Quite Low
Neurobehavioral 5 40.12 Quite Low
Inflammatory mediators 5 11.44 Low Low
Central nervous system 10 5.00 Very Low Very Low Very Low
Peripheral nervous system 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 115 99.36 Very High Very High Very High
Multiple Sclerosis 225 98.18 Very High Very High Very High
Targeted Disruption 65 91.92 High High
Disorder Of Lipid Metabolism 5 86.16 High High
Disease 70 76.24 Quite High
Peritonitis 35 48.04 Quite Low
Viral Meningitis 5 46.16 Quite Low
Aids-related Complex 5 17.12 Low Low
Paralysis 15 5.00 Very Low Very Low Very Low
Injury 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We showed that CCR2 expression is controlled at a post-transcriptional stage in some Ly6Clo monocytes and NK and T cells.
Regulation (controlled) of Gene_expression (expression) of CCR2 in T cells
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.42 Pain Relevance 0.10
In contrast, accumulation of the much less numerous Ly6Clocells was unaffected by CCR2 ablation (Fig 4D).
Neg (unaffected) Regulation (unaffected) of Gene_expression (ablation) of CCR2
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.45 Pain Relevance 0.07
RFP and CCR2 RNA expression in leukocytes
Regulation (leukocytes) of Gene_expression (expression) of CCR2 in leukocytes
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.06 Pain Relevance 0
Our EAE experiments revealed physiologically relevant and mechanistically intriguing functions of CCR2 expression and regulation of CNS myeloid inflammation.
Regulation (regulation) of Gene_expression (expression) of CCR2 associated with multiple sclerosis and inflammation
4) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 1.15 Pain Relevance 0.13
These results indicate possible post-transcriptional control of CCR2 expression.
Spec (possible) Regulation (control) of Gene_expression (expression) of CCR2
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965160 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

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