INT340687

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 5.00 Very Low Very Low Very Low
midbrain 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Machado-joseph Disease 12 97.08 Very High Very High Very High
Disease 25 90.72 High High
Toxicity 14 81.44 Quite High
Huntington's Chorea 3 54.04 Quite High
Alzheimer's Dementia 3 53.76 Quite High
Drug Induced Neurotoxicity 3 27.56 Quite Low
Targeted Disruption 23 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Spontaneous Abortion 1 5.00 Very Low Very Low Very Low
Ataxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we have demonstrated that alternative splicing of sequences distinct from the polyglutamine-encoding repeat can result in the production of an unstable, aggregate-prone ataxin-3 isoform, which results in increased insoluble aggregates in one murine model of SCA3.
Regulation (result) of Gene_expression (production) of ataxin-3 isoform associated with machado-joseph disease
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.67 Pain Relevance 0

General Comments

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