INT340698

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 3 28.60 Quite Low
Central nervous system 3 6.28 Low Low
midbrain 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 69 92.20 High High
Disease 75 85.24 High High
Machado-joseph Disease 36 83.56 Quite High
Toxicity 42 82.88 Quite High
Ataxia 3 46.16 Quite Low
Pathologic Processes 3 21.00 Low Low
Drug Induced Neurotoxicity 9 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 9 5.00 Very Low Very Low Very Low
Huntington's Chorea 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies implicate the third UIM in casein kinase 2-dependent ataxin-3 phosphorylation [39], a modification that influences nucleocytoplasmic shuttling and intranuclear aggregation of ataxin-3.
Regulation (kinase 2-dependent) of ataxin-3
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.57 Pain Relevance 0
These data suggest that C-terminal splice variation does not alter the basic DUB activities of ataxin-3 and are consistent with previous reports showing the greater importance of UIMs 1 and 2 for ubiquitin-related activities of this protein, [19], [30].
Neg (not) Regulation (alter) of ataxin-3
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0 Pain Relevance 0
We further show that although C-terminal splice isoform variation does not influence ataxin-3?
Neg (not) Regulation (influence) of ataxin-3
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.48 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox