INT340740

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.85
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CSPG5) Golgi apparatus (CSPG5) endoplasmic reticulum (CSPG5)
plasma membrane (CSPG5) intracellular (CSPG5)
Anatomy Link Frequency
villus 1
CSPG5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 96.08 Very High Very High Very High
rheumatoid arthritis 14 21.28 Low Low
cytokine 14 5.00 Very Low Very Low Very Low
tolerance 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 392 99.80 Very High Very High Very High
Wilms Tumor 28 99.02 Very High Very High Very High
INFLAMMATION 14 96.44 Very High Very High Very High
Toxicity 63 89.40 High High
Weight Gain 7 85.24 High High
Body Weight 7 85.04 High High
Lung Cancer 28 84.88 Quite High
Immunization 28 83.60 Quite High
Melanoma 77 81.56 Quite High
Non-small-cell Lung Cancer 49 81.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significance of NGc overexpression in human cancer is still under investigation.
Gene_expression (overexpression) of NGc associated with cancer
1) Confidence 0.30 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.78 Pain Relevance 0.04
Although initially it was suggested that NGc could be expressed in human tissues by an alternative metabolic pathway [17], nowadays plenty of evidence suggests that the presence of this sialic acid in human cancer is the result of the metabolic incorporation of dietary NGc [18, 19], as illustrated in Figure 1.
Gene_expression (expressed) of NGc associated with cancer
2) Confidence 0.30 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.33 Pain Relevance 0
In this regard, Wilms tumor gives the unique opportunity to learn about the expression of NGc gangliosides in diverse transformed cell lineages, comprising epithelial, stromal, and blastemal elements [39].
Gene_expression (expression) of NGc associated with wilms tumor
3) Confidence 0.26 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 1.06 Pain Relevance 0
In addition, in fetal tissues NGc can be detected in epithelial cells or secretions as well as the placental villus blood vessels [34].
Gene_expression (detected) of NGc in villus
4) Confidence 0.26 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 1.17 Pain Relevance 0.03
Expression of NGc in Human Tumors
Gene_expression (Expression) of NGc associated with cancer
5) Confidence 0.26 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 1.68 Pain Relevance 0.05
Tumor-specific expression of NGc-containing gangliosides in some human tumors suggests that the induction of an effective immune response against these antigens may be useful for patients with antigen-positive tumors.
Gene_expression (expression) of NGc associated with cancer
6) Confidence 0.26 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 1.69 Pain Relevance 0.05
In contrast to most mammals, including our closest relatives: the great apes, NGc is practically undetectable in healthy human tissues and fluids [10], since human cells lack the presence of CMAH [11].
Gene_expression (undetectable) of NGc
7) Confidence 0.20 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2965427 Disease Relevance 0.14 Pain Relevance 0

General Comments

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