INT340794

Context Info Confidence 0.65 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 4.50 Pain Relevance 0.33

Btla (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 24 87.36 Inflammation 45 86.56 corticosteroid 3 5.00 cINOD 3 5.00 Inflammatory response 3 5.00 imagery 3 5.00

Disease Link Frequency Relevance Heat Hypersensitivity 60 100.00 Cold Sores 159 99.32 Infection 117 99.08 Keratitis 111 98.60 INFLAMMATION 51 86.56 Disease 24 54.16 Herpes Simplex Virus Infection 9 50.00 Keloid Scars 3 40.08 Pressure And Volume Under Development 24 5.00 Sprains And Strains 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the present study, pBTLA treated mice showed a reduced DTH response two weeks after HSV-1 infection compared to pcDNA or PBS treated mice.

Localization (response) of pBTLA associated with cold sores, hypersensitivity and infection

1) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.91 Pain Relevance 0.17

concentrations were reduced in splenocytes isolated from pBTLA treated mice when stimulated in vitro, indicating that pBTLA treated mice had a reduced Th1 immune response.

Localization (response) of pBTLA

2) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.36 Pain Relevance 0.13

Comparison of the gD and BTLA binding sites on HVEM shows that the BTLA and gD binding sites are largely overlapping and involve similar structural motifs as well as similar energetics [12,40].

Localization (sites) of BTLA

3) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.22 Pain Relevance 0.03

General Comments

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