INT340813

Context Info Confidence 0.46 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.83 Pain Relevance 0.19

Anatomy Link Frequency corneas 1 T cell 1 Btla (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 30 79.64 cytokine 16 64.44 corticosteroid 2 5.00 cINOD 2 5.00 Inflammatory response 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Cold Sores 106 97.36 Infection 78 97.12 Necrosis 2 93.32 Cancer 2 92.96 Death 2 87.60 INFLAMMATION 34 79.64 Keratitis 74 75.24 Hypersensitivity 40 72.56 Herpes Simplex Virus 6 70.24 Viral Infection 2 66.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

BTLA is constitutively expressed by naïve CD4+ and CD8+ T cells and is further upregulated upon T cell activation [15].

Positive_regulation (upregulated) of BTLA in T cell

1) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.72 Pain Relevance 0.15

The gD mRNA levels in corneas from mice treated intraperitoneally with pBTLA and in, pcDNA3.1 treated mice and PBS control mice at 72 h after HSV-1 infection are shown in Figure 9.

Positive_regulation (treated) of pBTLA in corneas associated with cold sores and infection

2) Confidence 0.44 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.11 Pain Relevance 0.04

General Comments

This test has worked.