INT34085

Context Info Confidence 0.35 First Reported 1987 Last Reported 2011 Negated 0 Speculated 0 Reported most in Abstract Documents 16 Total Number 16 Disease Relevance 4.90 Pain Relevance 3.76

Anatomy Link Frequency temporomandibular joint 2 blood cells 2 neural 2 PGE (Mus musculus)

Pain Link Frequency Relevance Heat Clonidine 4 99.86 diclofenac 4 99.84 agonist 4 99.64 aspirin 14 99.52 Inflammation 40 99.20 antagonist 16 98.88 cINOD 21 98.36 Inflammatory mediators 3 97.28 depression 4 94.80 COX-2 inhibitor 4 89.48

Disease Link Frequency Relevance Heat Rhinitis 6 99.88 Chronic Renal Insufficiency 1 99.44 INFLAMMATION 46 99.20 Colitis 67 98.84 Cancer 47 98.08 Peritonitis 2 97.44 Renal Insufficiency 2 96.80 Ulcers 21 95.60 Depression 4 94.80 Esophageal Cancer 5 92.32

Sentences Mentioned In

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Anatomy

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Speculation

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Disease term

We have previously found that TLR4-deficient (TLR4-/-) mice demonstrate decreased expression of mucosal PGE 2 and are protected against colitis-associated neoplasia.

Negative_regulation (decreased) of Gene_expression (expression) of PGE associated with colitis and cancer

1) Confidence 0.35 Published 2010 Journal BMC Gastroenterol Section Abstract Doc Link PMC2912804 Disease Relevance 0.56 Pain Relevance 0

Our results demonstrated that paeonol inhibited LPS induced expression of NO, PGE(2) and IL-6.

Negative_regulation (inhibited) of Gene_expression (expression) of PGE

2) Confidence 0.32 Published 2009 Journal Am. J. Chin. Med. Section Abstract Doc Link 19222121 Disease Relevance 0.42 Pain Relevance 0.47

Agents that block PGE synthesis, nonsteroidal anti-inflammatory agents (NSAID), are widely used by people with renal insufficiency.

Negative_regulation (block) of Gene_expression (synthesis) of PGE associated with inflammation, renal insufficiency and cinod

3) Confidence 0.21 Published 1995 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 7780057 Disease Relevance 0.54 Pain Relevance 0.23

Inhibition of Egr-1 expression reduced substantially LPS-mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE(2) production.

Negative_regulation (decrease) of Gene_expression (production) of PGE

4) Confidence 0.21 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.12 Pain Relevance 0.08

NS-398 treatment of injured mice decreased PGE(2) production compared to T (3.9 +/- 0.3 vs 3.1 +/- 0.4 pg/microg protein), and significantly decreased IL-6, NO, and TNF-alpha production.

Negative_regulation (decreased) of Gene_expression (production) of PGE

5) Confidence 0.21 Published 2001 Journal J. Surg. Res. Section Abstract Doc Link 11368536 Disease Relevance 0.64 Pain Relevance 0.42

Our immunoblots revealed reduced expressions of COX-1 and COX-2 at peak ulceration, associated with reduced synthesis of serum and mucosal PGE.

Negative_regulation (reduced) of Gene_expression (synthesis) of PGE

6) Confidence 0.17 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952312 Disease Relevance 0.25 Pain Relevance 0.13

In the peritonitis model in mice, meloxicam was approximately twice as active as piroxicam, and more than 10 times as active as diclofenac in the suppression of PGE biosynthesis.

Negative_regulation (suppression) of Gene_expression (biosynthesis) of PGE associated with peritonitis and diclofenac

7) Confidence 0.07 Published 1996 Journal Biochem. Pharmacol. Section Abstract Doc Link 8534265 Disease Relevance 0.48 Pain Relevance 0.41

Rauwolscine (1 X 10(-8) and 1 X 10(-7) M) attenuated angiotensin II-induced PGE production and at a higher concentration (1 X 10(-6) M) reduced angiotensin III-induced PGE production.

Negative_regulation (attenuated) of Gene_expression (production) of PGE

8) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.09 Pain Relevance 0.33

Rauwolscine (1 X 10(-8) and 1 X 10(-7) M) attenuated angiotensin II-induced PGE production and at a higher concentration (1 X 10(-6) M) reduced angiotensin III-induced PGE production.

Negative_regulation (reduced) of Gene_expression (production) of PGE

9) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.08 Pain Relevance 0.34

The alpha-2 agonist, clonidine, both inhibited the nonadrenergic neural contraction and enhanced PGE synthesis.

Negative_regulation (inhibited) of Gene_expression (synthesis) of PGE in neural associated with agonist and clonidine

10) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.07 Pain Relevance 0.34

Yohimbine (1 X 10(-5) and 1 X 10(-4) M) also significantly reduced angiotensin II-induced prostaglandin E (PGE) synthesis.

Negative_regulation (reduced) of Gene_expression (synthesis) of PGE

11) Confidence 0.04 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.09 Pain Relevance 0.31

Following treatment with low concentrations of NS-398 (0.1 microM), PGE(2) production was reduced dramatically, indicating inhibition of COX-2 activity.

Negative_regulation (reduced) of Gene_expression (production) of PGE

12) Confidence 0.03 Published 2007 Journal Cancer Lett. Section Abstract Doc Link 17707579 Disease Relevance 0.76 Pain Relevance 0.12

CONCLUSION: This decrease in PGE(2) production in synovial fibroblasts could help elucidate the mechanism by which physical therapy, and in particular continuous passive motion, may decrease inflammatory mediators of the temporomandibular joint.

Negative_regulation (decrease) of Gene_expression (production) of PGE in temporomandibular joint

13) Confidence 0.02 Published 2003 Journal J. Oral Maxillofac. Surg. Section Body Doc Link 12796883 Disease Relevance 0 Pain Relevance 0

Considering the protective effect of exogenous PGE(2) on aspirin-induced bronchoconstriction and the interdependence of PGE(2) and cisteinyl leukotriene production, a reduced PGE(2) synthesis may render aspirin-sensitive patients more susceptible to the inhibitory effect of NSAIDs drugs and also lead to an increase in cysteinyl leukotriene release.

Negative_regulation (reduced) of Gene_expression (synthesis) of PGE associated with aspirin and cinod

14) Confidence 0.02 Published 2002 Journal Allergy Section Abstract Doc Link 12144557 Disease Relevance 0.38 Pain Relevance 0.31

Recent studies have reported that patients with AIAR have decreased activity of COX-2 and lower production of PGE(2) in the upper airway and peripheral blood cells.

Negative_regulation (decreased) of Gene_expression (production) of PGE in blood cells associated with rhinitis

15) Confidence 0.02 Published 2002 Journal Allergy Section Abstract Doc Link 12144557 Disease Relevance 0.42 Pain Relevance 0.28

RESULTS: Naproxen suppressed biosynthesis of PGE-M, prostacyclin metabolites and thromboxane metabolites and thrombomodulin levels.

Negative_regulation (suppressed) of Gene_expression (biosynthesis) of PGE-M

16) Confidence 0.00 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0

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