INT34086

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Context Info
Confidence 0.36
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.97
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RAW 264 2
PGE (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 3 99.92 Very High Very High Very High
antagonist 4 99.72 Very High Very High Very High
agonist 2 99.00 Very High Very High Very High
Inflammation 84 98.32 Very High Very High Very High
depression 1 91.08 High High
Pain 1 73.24 Quite High
cINOD 6 63.96 Quite High
COX2 3 56.12 Quite High
cytokine 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 96 98.32 Very High Very High Very High
Cancer 45 97.32 Very High Very High Very High
Inflammatory Bowel Disease 13 91.80 High High
Depression 1 91.08 High High
Disease 21 89.88 High High
Intestinal Cancer 3 86.96 High High
Fever 5 85.96 High High
Pain 1 73.24 Quite High
Colorectal Cancer 15 67.76 Quite High
Periodontal Disease 6 54.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have previously shown that TLR4-mediated signaling is responsible for mucosal Cox-2 expression and PGE 2 synthesis in the setting of intestinal inflammation [27].
Regulation (responsible) of Gene_expression (expression) of PGE associated with inflammation
1) Confidence 0.36 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2912804 Disease Relevance 0.98 Pain Relevance 0.25
LPS stimulation induced the coordinated synthesis of COX-2 and mPGES-1 that resulted in an enhanced production of PGE(2) in RAW 264.7 macrophages.
Regulation (resulted) of Gene_expression (production) of PGE in RAW 264
2) Confidence 0.22 Published 2010 Journal Cell. Signal. Section Abstract Doc Link 20546888 Disease Relevance 0.40 Pain Relevance 0.15
Furthermore, the comparison of 1 h to 6 h gene expression results showing M-values, fold changes and p values for PGE synthases and COX-2 are presented in Table 2.
Regulation (values) of Gene_expression (synthases) of PGE
3) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.05 Pain Relevance 0
To verify the reported involvement of alpha(2)-adrenoceptors (AR) in PGE(2) production, clonidine (alpha(2)-AR agonist, 2 mug/mul) was microdialyzed with and without SIN-1 or carboxy-PTIO.
Regulation (involvement) of Gene_expression (production) of PGE associated with agonist and clonidine
4) Confidence 0.06 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17584955 Disease Relevance 0.24 Pain Relevance 0.20
In contrast, limited reports exist regarding the regulation of the PGE synthases downstream of COX-2.
Regulation (regulation) of Gene_expression (synthases) of PGE
5) Confidence 0.05 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2873473 Disease Relevance 0.22 Pain Relevance 0.08
Yohimbine only significantly altered the angiotensin III-induced PGE synthesis at an antagonist concentration of 1 X 10(-4) M.
Regulation (altered) of Gene_expression (synthesis) of PGE associated with antagonist
6) Confidence 0.02 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027311 Disease Relevance 0.09 Pain Relevance 0.32

General Comments

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