INT340991

Context Info Confidence 0.08 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.20 Pain Relevance 0

signal transduction (VLDLR) transport (VLDLR) extracellular space (VLDLR) plasma membrane (VLDLR) nucleus (VLDLR)

Anatomy Link Frequency radial 2 VLDLR (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 20 5.00 Somatosensory cortex 16 5.00 gABA 12 5.00 anesthesia 4 5.00 alcohol 4 5.00 interneuron 4 5.00 Hippocampus 4 5.00 imagery 4 5.00

Disease Link Frequency Relevance Heat Disseminated Intravascular Coagulation 40 75.60 Malformations Of Cortical Development 28 61.96 Neurodegenerative Disease 24 5.00 Epilepsy 4 5.00 Syndrome 4 5.00 Schizophrenia 4 5.00 Intellectual Impairment 4 5.00 Injury 4 5.00 Autism 4 5.00 Disorder Of Lipid Metabolism 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We further investigated the effects induced by reelin and found that signaling was mediated via VLDLR/Dab1/Pi3K activation while NRG1 signaling was mediated via erbB3/erbB4/Pi3K.

Positive_regulation (activation) of VLDLR

1) Confidence 0.08 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0

Reelin affects the number of radial glial processes expressing BLBP via VLDLR/Dab1/Pi3K activation

Positive_regulation (activation) of VLDLR in radial

2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

The full length or the central fragment of reelin realigns disrupted radial glia via VLDLR/Dab1/Pi3K activation

Positive_regulation (activation) of VLDLR in radial

3) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.08 Pain Relevance 0

Activation of ApoER2, Dab1, and PI3K but not VLDLR and GSK3?

Positive_regulation (Activation) of VLDLR

4) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.06 Pain Relevance 0

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