INT341019

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.10
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (VLDLR, Reln) transport (VLDLR) cytoplasm (Reln)
peptidase activity (Reln) signal transduction (VLDLR) extracellular region (Reln)
Anatomy Link Frequency
neuronal 2
VLDLR (Homo sapiens)
Reln (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 4 99.72 Very High Very High Very High
gABA 12 39.36 Quite Low
cerebral cortex 20 28.28 Quite Low
Somatosensory cortex 16 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
interneuron 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 4 99.60 Very High Very High Very High
Malformations Of Cortical Development 28 46.08 Quite Low
Neurodegenerative Disease 24 14.60 Low Low
Disseminated Intravascular Coagulation 40 5.00 Very Low Very Low Very Low
Epilepsy 4 5.00 Very Low Very Low Very Low
Syndrome 4 5.00 Very Low Very Low Very Low
Schizophrenia 4 5.00 Very Low Very Low Very Low
Intellectual Impairment 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Autism 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reelin signaling requires binding to receptors of the lipoprotein family, very low density-lipoprotein (VLDLR) and the apolipoprotein E receptor (ApoER2), which triggers tyrosine phosphorylation of the cytoplasmic adapter protein Disabled-1 (Dab1) [34], [35], [36].
VLDLR Binding (binding) of Reelin associated with disorder of lipid metabolism
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0.10 Pain Relevance 0.05
Jossin et al. [56] demonstrate that the central fragment of reelin binds to ApoER2 and VLDLR but does not bind to cadherin-related neuronal receptors.
VLDLR Neg (not) Binding (bind) of reelin in neuronal
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
Jossin et al. [56] demonstrate that the central fragment of reelin binds to ApoER2 and VLDLR but does not bind to cadherin-related neuronal receptors.
VLDLR Binding (binds) of reelin in neuronal
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
RAP (300 nM) (human recombinant Receptor Associated Protein), prevents the binding of reelin to both ApoE2R and VLDLR [46], [47].
VLDLR Binding (binding) of reelin
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0

General Comments

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