INT34106

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 16
Disease Relevance 4.72
Pain Relevance 8.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr1a) plasma membrane (Htr1a) signal transducer activity (Htr1a)
Anatomy Link Frequency
blood 1
Htr1a (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 203 100.00 Very High Very High Very High
agonist 27 99.96 Very High Very High Very High
Serotonin 444 99.32 Very High Very High Very High
Calcium channel 3 98.80 Very High Very High Very High
antidepressant 277 98.68 Very High Very High Very High
Clonidine 7 98.12 Very High Very High Very High
Endocannabinoid 1 97.96 Very High Very High Very High
sSRI 30 97.40 Very High Very High Very High
Opioid 18 97.18 Very High Very High Very High
Analgesic 51 96.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypotension 3 99.74 Very High Very High Very High
Targeted Disruption 19 99.72 Very High Very High Very High
Endometriosis (extended) 104 98.60 Very High Very High Very High
Anxiety Disorder 21 98.24 Very High Very High Very High
Hyperalgesia 1 95.84 Very High Very High Very High
Myocardial Infarction 52 94.20 High High
Pain 86 93.68 High High
Coagulation Disorder 44 92.80 High High
Increased Venous Pressure Under Development 36 92.36 High High
INFLAMMATION 4 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore increased analgesic effect of opioids, as seen in our study in individuals with a triallelic 5-HTTLPR genotype coding for low 5-HTT expression, would be the expected result of a desensitization of 5-HT1a receptors.
Negative_regulation (desensitization) of 5-HT1a associated with analgesic and opioid
1) Confidence 0.57 Published 2009 Journal Mol Pain Section Body Doc Link PMC2717925 Disease Relevance 0.80 Pain Relevance 1.81
It was also shown that pretreatment with antagonists of 5HT1A and 5HT2A receptors antagonized antidepressant-like activity of SSRIs in the TST in mice (Miyata et al. 2004), suggesting that activation of both receptors plays a key role in the action of compounds acting via activation of the serotonergic system in this test.
Negative_regulation (antagonists) of 5HT1A associated with antidepressant, antagonist and ssri
2) Confidence 0.42 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.68
Evidence that 5-HT1A receptor inactivation increases the therapeutic effects of antidepressants has also been presented.
Negative_regulation (inactivation) of 5-HT1A associated with antidepressant
3) Confidence 0.42 Published 2001 Journal Brain Res. Section Abstract Doc Link 11376590 Disease Relevance 0.26 Pain Relevance 0.34
Lithium decreases 5-HT1A and 5-HT2 receptor and alpha 2-adrenoceptor mediated function in mice.
Negative_regulation (decreases) of 5-HT1A
4) Confidence 0.41 Published 1986 Journal Psychopharmacology (Berl.) Section Title Doc Link 3027734 Disease Relevance 0.06 Pain Relevance 0.14
This effect resulted probably from a blockade of 5HT1A autoreceptors by 5HT1A antagonists and a subsequent increase in the level of serotonin.
Negative_regulation (blockade) of 5HT1A associated with antagonist and serotonin
5) Confidence 0.41 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.89
CB1 knockout mice display impaired functionality of 5-HT1A and 5-HT2A/C receptors.
Negative_regulation (impaired) of 5-HT1A associated with targeted disruption
6) Confidence 0.41 Published 2007 Journal J. Neurochem. Section Title Doc Link 17944876 Disease Relevance 0.51 Pain Relevance 0.35
We conclude that calcium channel blockade abolishes the blood pressure lowering response of V1 receptor blockade in blacks.
Negative_regulation (blockade) of V1 receptor in blood associated with calcium channel and hypotension
7) Confidence 0.20 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9370387 Disease Relevance 0.10 Pain Relevance 0.27
In the presence of clonidine, there were similar reductions in arterial pressure in both groups (P = .026) with a further reduction following V1 receptor blockade only in the blacks (-7 +/- 3 delta mm Hg blacks versus 6 +/- 2 delta mm Hg whites; P < .001).
Negative_regulation (reduction) of V1 receptor associated with clonidine
8) Confidence 0.20 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9370387 Disease Relevance 0.06 Pain Relevance 0.29
In the presence of clonidine, there were similar reductions in arterial pressure in both groups (P = .026) with a further reduction following V1 receptor blockade only in the blacks (-7 +/- 3 delta mm Hg blacks versus 6 +/- 2 delta mm Hg whites; P < .001).
Negative_regulation (blockade) of V1 receptor associated with clonidine
9) Confidence 0.20 Published 1997 Journal Am. J. Hypertens. Section Abstract Doc Link 9370387 Disease Relevance 0.06 Pain Relevance 0.29
Our study shows that the action of the group II mGlu receptors antagonist, MGS0039, was not significantly potentiated by an antagonist of the 5HT1A receptor, WAY100635, further confirming that the mechanism of the antidepressant-like activity of MGS0039 was not serotonin-dependent.
Negative_regulation (antagonist) of 5HT1A receptor associated with antidepressant, antagonist and serotonin
10) Confidence 0.02 Published 2010 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2981731 Disease Relevance 0 Pain Relevance 0.88
Based on insights into the basic pathophysiological mechanisms of the disorder, some drugs have been developed which seem promising in early phase II studies (NOS inhibitors and 5HT1F-receptor agonists).
Negative_regulation (inhibitors) of 5HT1F-receptor associated with agonist
11) Confidence 0.01 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19795182 Disease Relevance 0.58 Pain Relevance 0.82
In addition, the concurrent inactivation of 5HT1A receptors decreases TNF-?
Negative_regulation (inactivation) of 5HT1A
12) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.53 Pain Relevance 0.15
In addition, testosterone, which increases following menopause, compounds the actions of serotonin at 5HT1A receptors by preventing desensitization of 5HT1A receptors [97].
Negative_regulation (desensitization) of 5HT1A associated with endometriosis (extended) and serotonin
13) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.56 Pain Relevance 0.20
Normal physiology depends on maintaining a balance between 5HT2A receptor produced Ca++ inflow and 5HT1A receptor suppression of cAMP production.
Negative_regulation (suppression) of 5HT1A
14) Confidence 0.01 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.18 Pain Relevance 0.49
Using 5-MeOT as the prototype agonist, cyanopindolol blocked contraction with an antagonist dissociation constant lower than expected for 5-HT1-receptor blockade and ICS 205-930 (10 microM) did not affect 5-MeOT-induced contraction.
Negative_regulation (blockade) of 5-HT1-receptor associated with antagonist and agonist
15) Confidence 0.00 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8423526 Disease Relevance 0 Pain Relevance 0.60
With reduced levels of E2, 5HT1A receptors are disinhibited and counter the effects of 5HT2A receptor activation.
Negative_regulation (reduced) of 5HT1A
16) Confidence 0.00 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0 Pain Relevance 0.53

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