INT341163

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.56
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif4e) translation (Eif4e) protein complex (Eif4e)
cytoplasm (Eif4e)
Eif4e (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 144 98.98 Very High Very High Very High
cerebral cortex 40 79.28 Quite High
alcohol 4 19.84 Low Low
addiction 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 140 98.98 Very High Very High Very High
Stress 112 97.86 Very High Very High Very High
Cv General 4 Under Development 4 22.52 Low Low
Glioma 4 21.28 Low Low
Alzheimer's Dementia 4 20.96 Low Low
Toxicity 4 20.20 Low Low
Brain Disease 4 18.80 Low Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Cancer 24 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the model described here, signaling pathways leading to Thr36/Thr45 phosphorylation would induce the release of 4E-BP1 from eIF4E and eIF4E activation.
Positive_regulation (activation) of eIF4E
1) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.13 Pain Relevance 0.03
In the model described here, signaling pathways leading to Thr36/Thr45 phosphorylation would induce the release of 4E-BP1 from eIF4E and eIF4E activation.
Positive_regulation (activation) of eIF4E
2) Confidence 0.54 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.13 Pain Relevance 0.03
IR stress during short term reperfusion induced a significant decrease in 4E-BP1/eIF4E association, parallel to the increased eIF4G/eIF4E association and in accordance with the induced 4E-BP1 phosphorylation at Thr36/Thr45 and Ser64, in addition to Thr69.
Positive_regulation (increased) of eIF4E associated with stress
3) Confidence 0.39 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.10 Pain Relevance 0
R30 induced a significant decrease in 4E-BP1 bound to eIF4E when compared with the SHC control or I15 condition, and accordingly, induced a significant increase in eIF4G/eIF4E association (Fig. 4; supplemental Fig.
Positive_regulation (increase) of eIF4E associated with ischemia
4) Confidence 0.36 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.19 Pain Relevance 0.14

General Comments

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