INT341167

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.23
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Eif4e) translation (Eif4e) protein complex (Eif4e)
cytoplasm (Eif4e)
Eif4e (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 72 50.12 Quite High
alcohol 2 47.44 Quite Low
cerebral cortex 20 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 56 66.96 Quite High
Cv General 4 Under Development 2 50.12 Quite High
Cv Unclassified Under Development 70 50.00 Quite Low
Glioma 2 48.88 Quite Low
Alzheimer's Dementia 2 48.56 Quite Low
Toxicity 2 47.80 Quite Low
Brain Disease 2 46.40 Quite Low
Hypoxia 12 30.32 Quite Low
Cancer 12 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Ser64 phosphorylation might be dispensable for dissociation from eIF4E (29), and it has suggested that phosphorylation at this site prevents the reassociation of eIF4E and 4E-BP1 (37).
Negative_regulation (prevents) of eIF4E Binding (reassociation) of
1) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.23 Pain Relevance 0.03
Phosphorylation of Thr36/Thr45 does not regulate the binding of 4E-BP1 to eIF4E directly (6), whereas phosphorylation at Ser64 and Thr69 is insufficient to prevent binding to eIF4E (10).
Negative_regulation (prevent) of eIF4E Binding (binding) of
2) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

General Comments

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