INT341172

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 4.42
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
brain 3
cerebral cortex 1
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 360 98.88 Very High Very High Very High
alcohol 10 97.84 Very High Very High Very High
cerebral cortex 100 95.64 Very High Very High Very High
addiction 10 10.56 Low Low
anesthesia 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 280 99.92 Very High Very High Very High
Brain Disease 10 99.16 Very High Very High Very High
Cv Unclassified Under Development 350 98.88 Very High Very High Very High
Cancer 60 98.72 Very High Very High Very High
Toxicity 10 97.52 Very High Very High Very High
Alzheimer's Dementia 10 97.12 Very High Very High Very High
Repression 10 96.80 Very High Very High Very High
Glioma 10 96.36 Very High Very High Very High
Cv General 4 Under Development 10 95.56 Very High Very High Very High
Hypoxia 60 93.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, no data are available about the phosphorylation sites for 4E-BP1 regulation under physiological conditions, and information about this might be important for cancer control.
Regulation (regulation) of 4E-BP1 associated with cancer
1) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.54 Pain Relevance 0
This study reports a physiological study of 4E-BP1 regulation by phosphorylation using control conditions and a stress-induced translational repression condition, ischemia-reperfusion (IR) stress, in brain tissue.
Regulation (regulation) of 4E-BP1 in brain associated with stress, ischemia and repression
2) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2966049 Disease Relevance 0.63 Pain Relevance 0.09
IR with long term reperfusion (R3d) did not induce any significant effect on 4E-BP1 phospho-forms in comparison with the SHC3d control (Fig. 1, 4E-BP1).
Regulation (control) of 4E-BP1
3) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.68 Pain Relevance 0.25
These results demonstrate a new hierarchical phosphorylation for 4E-BP1 regulation in which Thr69 is phosphorylated first followed by Thr36/Thr45 phosphorylation, and Ser64 is phosphorylated last.
Regulation (regulation) of 4E-BP1
4) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2966049 Disease Relevance 0.51 Pain Relevance 0.07
However, 4E-BP1 has been described as a specific target in several specific brain diseases, such as cerebral alcohol toxicity, Alzheimer disease, glioma (32–34), and cerebral ischemia (16, 35), which indicates a particular role for 4E-BP1 in brain.
Regulation (target) of 4E-BP1 in brain associated with toxicity, cv general 4 under development, brain disease, ischemia, alzheimer's dementia, glioma and alcohol
5) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.62 Pain Relevance 0.10
4E-BP1 is one of the two best characterized targets of mTORC1, which is crucial in cancer control (48). 4E-BP1 has a key role in cancer because its inactivation by phosphorylation leads to increased eIF4F complex formation, and consequently, enhanced cap-dependent translation and cell growth.
Regulation (targets) of 4E-BP1 associated with cancer
6) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.40 Pain Relevance 0
4E-BP1 is a direct target of mTORC1, which is known to control 4E-BP1 activity.
Regulation (target) of 4E-BP1
7) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.22 Pain Relevance 0.03
This compelling evidence has been reported in stimulated cultured cells, including cell lines and transfected cells, and the physiological roles of these phosphorylation reactions in the normal control of 4E-BP1 remain to be fully established (6).
Regulation (control) of 4E-BP1
8) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.25 Pain Relevance 0
The present study was a physiological investigation of 4E-BP1 regulation by phosphorylation, using control conditions and ischemic and IR stress in brain tissue, and described a new hierarchical phosphorylation of 4E-BP1.
Spec (investigation) Regulation (regulation) of 4E-BP1 in brain associated with stress
9) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.37 Pain Relevance 0.05
No significant changes in 4E-BP1 and eIF4G/eIF4E association were found in the R3d group when compared with the SHC3d control or between the cerebral cortex and hippocampal CA1 region (supplemental Fig.
Neg (No) Regulation (changes) of 4E-BP1 in cerebral cortex associated with cerebral cortex
10) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.19 Pain Relevance 0.17

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