INT341181

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 4.99
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
brain 2
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 648 99.90 Very High Very High Very High
cerebral cortex 180 94.00 High High
addiction 18 86.92 High High
alcohol 18 17.40 Low Low
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 504 99.98 Very High Very High Very High
Cv Unclassified Under Development 630 99.90 Very High Very High Very High
Hypoxia 108 95.40 Very High Very High Very High
Cancer 108 92.48 High High
Repression 18 75.92 Quite High
Cv General 4 Under Development 18 20.08 Low Low
Glioma 18 18.84 Low Low
Alzheimer's Dementia 18 18.52 Low Low
Toxicity 18 17.76 Low Low
Brain Disease 18 16.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of mTORC1 results in phosphorylation of 4E-BP1 at Thr36, Thr45, Ser64, and Thr69 sites and the release of 4E-BP1 from eIF4E (6, 7).
Positive_regulation (results) of Phosphorylation (phosphorylation) of 4E-BP1
1) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
We hypothesize that in brain tissue, the mTORC1 signal could be primarily operating through TOS motif, inducing 4E-BP1 phosphorylation at Thr69.
Positive_regulation (inducing) of Phosphorylation (phosphorylation) of 4E-BP1 in brain
2) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.42 Pain Relevance 0
However, during short term but not long term reperfusion, phosphorylation of 4E-BP1 was increased above the control level, with a significant increase in the hyperphosphorylated ?
Positive_regulation (increased) of Phosphorylation (phosphorylation) of 4E-BP1
3) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.32 Pain Relevance 0.05
Insulin treatment of cells after deprivation is known to modify phosphorylation of 4E-BP1 at Thr36/Thr45 as the first event in cell lines (9, 23, 29, 37).
Positive_regulation (modify) of Phosphorylation (phosphorylation) of 4E-BP1
4) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0.05
The hierarchical phosphorylation of 4E-BP1 at these sites is stimulated by agents such as insulin, growth factors and serum, and in many cell types, this effect requires the presence of amino acids in the culture medium.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of 4E-BP1
5) Confidence 0.30 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
These results conclude a new hierarchical phosphorylation for 4E-BP1 in which Thr69 phosphorylation is the priming event for subsequent phosphorylation of Thr36/Thr45, which precedes phosphorylation of Ser64.
Positive_regulation (event) of Phosphorylation (phosphorylation) of 4E-BP1
6) Confidence 0.22 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.11 Pain Relevance 0
IR stress during short term reperfusion induced a significant decrease in 4E-BP1/eIF4E association, parallel to the increased eIF4G/eIF4E association and in accordance with the induced 4E-BP1 phosphorylation at Thr36/Thr45 and Ser64, in addition to Thr69.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of 4E-BP1 associated with stress
7) Confidence 0.22 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.10 Pain Relevance 0
Phosphorylation-dependent 4E-BP1 activity is controlled by mTORC1, which is known to operate as an oxygen and energy sensor for the cells, because hypoxia and energy deprivation induce mTORC1 inhibition (11).
Positive_regulation (dependent) of Phosphorylation (Phosphorylation) of 4E-BP1 associated with hypoxia
8) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.39 Pain Relevance 0.07
Ischemic stress induced 4E-BP1 dephosphorylation at Thr69, Thr36/Thr45, and Ser64 residues, with 4E-BP1 remaining phosphorylated at Thr69 alone or dephosphorylated.
Positive_regulation (induced) of Phosphorylation (dephosphorylation) of 4E-BP1 associated with stress
9) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.15 Pain Relevance 0
Long term reperfusion (R3d) did not induce any significant effect on 4E-BP1 phosphorylation with respect to the SHC3d control (Fig. 1; supplemental Figs.
Neg (not) Positive_regulation (induce) of Phosphorylation (phosphorylation) of 4E-BP1
10) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.28 Pain Relevance 0.19
Ischemic stress induced 4E-BP1 dephosphorylation at Thr69, Thr36/Thr45, and Ser64 residues, with 4E-BP1 remaining phosphorylated at Thr69 alone or dephosphorylated.
Positive_regulation (induced) of Phosphorylation (dephosphorylation) of 4E-BP1 associated with stress
11) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2966049 Disease Relevance 0.62 Pain Relevance 0.08
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Positive_regulation (restored) of Phosphorylation (phosphorylation) of 4E-BP1
12) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.34 Pain Relevance 0.05
In the subsequent reperfusion, 4E-BP1 phosphorylation was induced at Thr36/Thr45 and Ser64, in addition to Thr69.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of 4E-BP1
13) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2966049 Disease Relevance 0.58 Pain Relevance 0.07
The hierarchical phosphorylation of 4E-BP1 at these sites is stimulated by agents such as insulin, growth factors and serum, and in many cell types, this effect requires the presence of amino acids in the culture medium.
Positive_regulation (requires) of Phosphorylation (phosphorylation) of 4E-BP1
14) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
Previously, we have reported dephosphorylation of 4E-BP1 after ischemia and induction of 4E-BP1 phosphorylation during short term reperfusion (16).
Positive_regulation (induction) of Phosphorylation (phosphorylation) of 4E-BP1 associated with ischemia
15) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 1.07 Pain Relevance 0.25
In the subsequent reperfusion period, 4E-BP1 phosphorylation was induced at Thr36/Thr45 and Ser64, in addition to Thr69.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of 4E-BP1
16) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0
The subsequent reperfusion or insulin treatment induced 4E-BP1 phosphorylation at Thr36/Thr45 and Ser64, in addition to Thr69 (supplemental Fig.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of 4E-BP1
17) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.13 Pain Relevance 0.04
Activation of mTORC1 leads to hyperphosphorylation of 4E-BP1, and therefore, the phosphorylation status of 4E-BP1 is an indicator of mTORC1 activity (6, 7, 38).
Positive_regulation (leads) of Phosphorylation (hyperphosphorylation) of 4E-BP1
18) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.28 Pain Relevance 0.03

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