INT341203

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.86
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
cerebral cortex 1
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 60 96.76 Very High Very High Very High
ischemia 216 96.44 Very High Very High Very High
alcohol 6 46.92 Quite Low
addiction 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 210 96.44 Very High Very High Very High
Stress 168 90.24 High High
Cancer 36 49.68 Quite Low
Cv General 4 Under Development 6 49.60 Quite Low
Glioma 6 48.36 Quite Low
Alzheimer's Dementia 6 48.04 Quite Low
Toxicity 6 47.28 Quite Low
Brain Disease 6 45.88 Quite Low
Hypoxia 36 21.52 Low Low
Repression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, RAIP motif seems to be independent of the 4E-BP1/raptor interaction and may interact with another putative partner protein (7, 9, 23).
4E-BP1 Binding (interaction) of
1) Confidence 0.21 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.07 Pain Relevance 0
However, Ser64 phosphorylation might be dispensable for dissociation from eIF4E (29), and it has suggested that phosphorylation at this site prevents the reassociation of eIF4E and 4E-BP1 (37).
4E-BP1 Binding (reassociation) of
2) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.18 Pain Relevance 0
Phosphorylation of Thr36/Thr45 does not regulate the binding of 4E-BP1 to eIF4E directly (6), whereas phosphorylation at Ser64 and Thr69 is insufficient to prevent binding to eIF4E (10).
4E-BP1 Binding (binding) of
3) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
No significant changes in 4E-BP1 and eIF4G/eIF4E association were found in the R3d group when compared with the SHC3d control or between the cerebral cortex and hippocampal CA1 region (supplemental Fig.
4E-BP1 Binding (association) of in cerebral cortex associated with cerebral cortex
4) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.19 Pain Relevance 0.17
form of 4E-BP1 were specific forms bound to eIF4E.
4E-BP1 Binding (bound) of
5) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.28 Pain Relevance 0.12
Two-dimensional gel electrophoresis and Western blotting of 4E-BP1 bound to eIF4E detected the ?
4E-BP1 Binding (bound) of
6) Confidence 0.16 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.14 Pain Relevance 0.16

General Comments

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