INT341207

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.13
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Eif4ebp1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 144 50.40 Quite High
alcohol 4 5.16 Low Low
cerebral cortex 40 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 112 81.04 Quite High
Cv Unclassified Under Development 140 50.40 Quite High
Cv General 4 Under Development 4 7.84 Low Low
Glioma 4 6.60 Low Low
Alzheimer's Dementia 4 6.28 Low Low
Toxicity 4 5.52 Low Low
Hypoxia 24 5.00 Very Low Very Low Very Low
Cancer 24 5.00 Very Low Very Low Very Low
Repression 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the model described here, signaling pathways leading to Thr36/Thr45 phosphorylation would induce the release of 4E-BP1 from eIF4E and eIF4E activation.
Localization (release) of 4E-BP1
1) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.13 Pain Relevance 0.03
Activation of mTORC1 results in phosphorylation of 4E-BP1 at Thr36, Thr45, Ser64, and Thr69 sites and the release of 4E-BP1 from eIF4E (6, 7).
Localization (release) of 4E-BP1
2) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
Activation of mTORC1 results in phosphorylation of 4E-BP1 at Thr36, Thr45, Ser64, and Thr69 sites and the release of 4E-BP1 from eIF4E (6, 7).
Localization (release) of 4E-BP1
3) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0
Phosphorylation of the other three sites appears not to be regulated (6, 9). 4E-BP1 is one of the main effectors of mammalian target of rapamycin (mTOR), serine/threonine-protein kinase in the phosphoinositide 3-kinase (PI3-kinase)/Akt (RAC serine/threonine-protein kinase, also named protein kinase B, PKB) signaling pathway that integrates signals from extracellular stimuli, amino acid availability, and oxygen and energy status of the cells (8). 4E-BPs contain a TOR signaling (TOS) motif that binds the mTOR complex 1 (mTORC1) (6). mTORC1 controls the activity of 4E-BP1.
Localization (target) of 4E-BP1
4) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0 Pain Relevance 0

General Comments

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