INT341220

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.42
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Eif4e, Eif4ebp1) cytoplasm (Eif4e, Eif4ebp1) RNA binding (Eif4e)
nucleus (Eif4ebp1) translation (Eif4e)
Eif4e (Mus musculus)
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 36 57.44 Quite High
alcohol 1 54.76 Quite High
cerebral cortex 10 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 28 74.28 Quite High
Cv General 4 Under Development 1 57.44 Quite High
Glioma 1 56.20 Quite High
Alzheimer's Dementia 1 55.88 Quite High
Toxicity 1 55.12 Quite High
Brain Disease 1 53.72 Quite High
Cv Unclassified Under Development 35 50.00 Quite Low
Hypoxia 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation at Ser64 and Thr69 seems to regulate binding to eIF4E, but these phosphorylation reactions alone are insufficient to block binding to eIF4E, which indicates that combination with Thr36/Thr45 phosphorylation is necessary to dissociate 4E-BP1 from eIF4E (6, 10, 36).
eIF4E Positive_regulation (dissociate) of 4E-BP1
1) Confidence 0.20 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.42 Pain Relevance 0.06

General Comments

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