INT341233

Context Info Confidence 0.06 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0

cytoplasm (EIF4E, Eif4ebp1) cytosol (EIF4E) nucleus (Eif4ebp1) translation (EIF4E) protein complex (Eif4ebp1)

EIF4E (Homo sapiens) Eif4ebp1 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 36 50.00 cerebral cortex 10 5.00 addiction 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Cancer 6 100.00 Cv Unclassified Under Development 35 50.00 Stress 28 50.00 Hypoxia 6 5.00 Toxicity 1 5.00 Repression 1 5.00 Body Weight 1 5.00 Cv General 4 Under Development 1 5.00 Brain Disease 1 5.00 Alzheimer's Dementia 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

4E-BP1 is one of the two best characterized targets of mTORC1, which is crucial in cancer control (48). 4E-BP1 has a key role in cancer because its inactivation by phosphorylation leads to increased eIF4F complex formation, and consequently, enhanced cap-dependent translation and cell growth.

Positive_regulation (increased) of eIF4F Binding (formation) of 4E-BP1 associated with cancer

1) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.50 Pain Relevance 0

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