INT341233

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Context Info
Confidence 0.06
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (EIF4E, Eif4ebp1) cytosol (EIF4E) nucleus (Eif4ebp1)
translation (EIF4E) protein complex (Eif4ebp1)
EIF4E (Homo sapiens)
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 36 50.00 Quite Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 100.00 Very High Very High Very High
Cv Unclassified Under Development 35 50.00 Quite Low
Stress 28 50.00 Quite Low
Hypoxia 6 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low
Brain Disease 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
4E-BP1 is one of the two best characterized targets of mTORC1, which is crucial in cancer control (48). 4E-BP1 has a key role in cancer because its inactivation by phosphorylation leads to increased eIF4F complex formation, and consequently, enhanced cap-dependent translation and cell growth.
Positive_regulation (increased) of eIF4F Binding (formation) of 4E-BP1 associated with cancer
1) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.50 Pain Relevance 0

General Comments

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