INT341236

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) nucleus (Eif4ebp1)
plasma membrane (ROS1) protein complex (Eif4ebp1) cytoplasm (Eif4ebp1)
Anatomy Link Frequency
PP2A 2
ROS1 (Homo sapiens)
Eif4ebp1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 36 71.72 Quite High
cerebral cortex 10 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 35 71.72 Quite High
Hypoxia 6 67.64 Quite High
Stress 28 59.88 Quite High
Cancer 6 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Repression 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low
Brain Disease 1 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, it has been reported that ROS inhibit protein phosphatase 2A (PP2A) (41, 42), phosphatase activity that has been implicated in regulation of 4E-BP1 phosphorylation (7, 30, 43). 4E-BP1 phosphorylation at Ser64, but not Thr69, is induced by ROS (44).
ROS Positive_regulation (induced) of Phosphorylation (phosphorylation) of 4E-BP1 in PP2A
1) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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