INT341237

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r1a) cell differentiation (ROS1) cell proliferation (ROS1)
chromosome segregation (Ppp2r1a) chromosome (Ppp2r1a) plasma membrane (ROS1)
Anatomy Link Frequency
PP2A 1
ROS1 (Homo sapiens)
Ppp2r1a (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 72 77.76 Quite High
cerebral cortex 20 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 56 92.44 High High
Cv Unclassified Under Development 70 77.76 Quite High
Hypoxia 12 73.68 Quite High
Cancer 12 9.04 Low Low
Toxicity 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 2 5.00 Very Low Very Low Very Low
Brain Disease 2 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, the increase in Thr308 and Ser473 phosphorylation in short term reperfusion could be explained by the inhibition of PP2A by ROS because PP2A has been described as an Akt phosphatase (47).
ROS Negative_regulation (inhibition) of PP2A
1) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.09 Pain Relevance 0
Also, it has been reported that ROS inhibit protein phosphatase 2A (PP2A) (41, 42), phosphatase activity that has been implicated in regulation of 4E-BP1 phosphorylation (7, 30, 43). 4E-BP1 phosphorylation at Ser64, but not Thr69, is induced by ROS (44).
ROS Negative_regulation (inhibit) of PP2A in PP2A
2) Confidence 0.01 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.22 Pain Relevance 0.04

General Comments

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