INT341308

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.48
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Npc1, Srebf1) endoplasmic reticulum (Npc1, Srebf1) endosome (Npc1)
nuclear envelope (Npc1) DNA binding (Srebf1) protein complex (Srebf1)
Anatomy Link Frequency
macrophages 5
fibroblasts 1
Npc1 (Mus musculus)
Srebf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 14 93.08 High High
Disease 8 84.40 Quite High
Apoptosis 6 77.00 Quite High
Atherosclerosis 24 70.28 Quite High
Death 2 67.36 Quite High
Coronary Artery Disease 84 61.52 Quite High
Atherosclerotic Plaque 4 59.28 Quite High
Congenital Anomalies 2 55.08 Quite High
Genetic Predisposition To Disease 2 50.96 Quite High
Nicotine Addiction 60 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].
Negative_regulation (Loss) of NPC1 in macrophages Positive_regulation (leads) of Gene_expression (expression) of sterol regulatory element binding protein in macrophages
1) Confidence 0.31 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.74 Pain Relevance 0
Loss of NPC1 function leads to defective suppression of sterol regulatory element binding protein (SREBP)-dependent gene expression and failure to appropriately activate liver X receptor-mediated pathways, ultimately resulting in intracellular cholesterol accumulation in macrophages and fibroblasts[7,8].
Negative_regulation (Loss) of NPC1 in macrophages Positive_regulation (leads) of in fibroblasts Gene_expression (expression) of sterol regulatory element binding protein in macrophages
2) Confidence 0.10 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 0.74 Pain Relevance 0

General Comments

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