INT341310

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.11
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 7.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) mitochondrion (Chdh) nuclear envelope (Npc1)
oxidoreductase activity (Chdh) Golgi apparatus (Npc1) endoplasmic reticulum (Npc1)
Anatomy Link Frequency
heart 1
Npc1 (Mus musculus)
Chdh (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 5 5.00 Very Low Very Low Very Low
Inflammatory response 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 210 100.00 Very High Very High Very High
Nicotine Addiction 150 100.00 Very High Very High Very High
Diabetes Mellitus 45 90.00 High High
Hypertension 35 88.92 High High
Obesity 40 88.36 High High
Disease 20 84.52 Quite High
Atherosclerosis 60 84.20 Quite High
Apoptosis 15 71.68 Quite High
Necrosis 5 70.32 Quite High
Stress 10 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the biological basis of NPC1-smoking interaction on lipid concentration and CHD risk is still unclear.
NPC1 Binding (interaction) of CHD associated with coronary artery disease and nicotine addiction
1) Confidence 0.11 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.43 Pain Relevance 0
However, the biological basis of NPC1-smoking interaction on lipid concentration and CHD risk is still unclear.
NPC1 Binding (interaction) of CHD associated with coronary artery disease and nicotine addiction
2) Confidence 0.08 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.43 Pain Relevance 0
This study aims to investigate whether the genetic variation in NPC1 is associated with risk of coronary heart disease (CHD) and to detect whether NPC1 might interact with smoking on the risk of CHD.


NPC1 Spec (might) Binding (interact) of CHD in heart associated with nicotine addiction and coronary artery disease
3) Confidence 0.08 Published 2010 Journal BMC Med Genet Section Abstract Doc Link PMC2966454 Disease Relevance 0.96 Pain Relevance 0
In multiplicative interaction mode, there was a significant interaction between NPC1 genotype and cigarette smoking on risk for CHD (P for interaction = 0.0001).
NPC1 Binding (interaction) of CHD associated with coronary artery disease and nicotine addiction
4) Confidence 0.08 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.81 Pain Relevance 0
Furthermore in multiplicative interaction mode, there was a significant interaction between NPC1 +644A > G and cigarette smoking on risk for CHD.
NPC1 Binding (interaction) of CHD associated with coronary artery disease and nicotine addiction
5) Confidence 0.07 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox