INT34132

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.15
Pain Relevance 4.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
brain 1
Oprk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 16 100.00 Very High Very High Very High
tolerance 1 100.00 Very High Very High Very High
agonist 21 99.96 Very High Very High Very High
addiction 26 99.80 Very High Very High Very High
Dynorphin 5 99.72 Very High Very High Very High
Morphine 47 99.50 Very High Very High Very High
Antihyperalgesic 3 99.48 Very High Very High Very High
MU agonist 8 97.92 Very High Very High Very High
Analgesic 28 97.48 Very High Very High Very High
Pain 37 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Alcohol Addiction 8 99.80 Very High Very High Very High
Drug Dependence 6 99.44 Very High Very High Very High
Pain 33 96.32 Very High Very High Very High
Nociception 3 96.04 Very High Very High Very High
Urological Neuroanatomy 4 81.84 Quite High
Opiate Addiction 6 78.04 Quite High
Cocaine Dependence 4 77.64 Quite High
Neuropathic Pain 5 75.00 Quite High
Sleep Disorders 6 71.76 Quite High
Catatonia 2 67.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dynorphin A levels and kappa-opioid receptor binding were measured on day 8 (3 d after the last injection) or 22 (17 d after the last injection).
kappa-opioid receptor Binding (binding) of associated with dynorphin and kappa opioid receptor
1) Confidence 0.48 Published 2004 Journal J. Mol. Neurosci. Section Abstract Doc Link 15456944 Disease Relevance 0.27 Pain Relevance 0.65
When transiently expressed in COS-7 cells this receptor did not bind any of the typical mu, delta or kappa opioid receptor ligands with high affinity.
kappa opioid receptor Neg (not) Binding (bind) of associated with kappa opioid receptor
2) Confidence 0.36 Published 1994 Journal FEBS Lett. Section Abstract Doc Link 8034019 Disease Relevance 0 Pain Relevance 0.60
These results suggest that in mononeuropathic rats, morphine pretreatment results in cross-tolerance to delta- but not to kappa-opioid receptor agonists.
kappa-opioid receptor Binding (cross-tolerance) of associated with agonist, kappa opioid receptor, tolerance and morphine
3) Confidence 0.34 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016915 Disease Relevance 0.07 Pain Relevance 1.46
Taken together, our findings supported a positive association between OPRD1 variants and SD, and a positive haplotypic association between OPRK1 and AD in EAs.
OPRK1 Binding (association) of associated with addiction
4) Confidence 0.28 Published 2008 Journal Mol. Psychiatry Section Abstract Doc Link 17622222 Disease Relevance 1.08 Pain Relevance 0.58
Guanine nucleotide and cation regulation of mu, delta, and kappa opioid receptor binding: evidence for differential postnatal development in rat brain.
kappa opioid receptor Binding (binding) of in brain associated with kappa opioid receptor
5) Confidence 0.22 Published 1987 Journal J. Neurochem. Section Title Doc Link 3029328 Disease Relevance 0 Pain Relevance 0.22
In contrast to mu-receptor agonism, kappa-2 receptor binding produces an antihyperalgesic effect, but is not considered an analgesic, as sensitivity to normal nociceptive stimuli is not affected.
kappa-2 receptor Binding (binding) of associated with nociception, antihyperalgesic and analgesic
6) Confidence 0.07 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC2045099 Disease Relevance 0.72 Pain Relevance 1.27

General Comments

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