INT341372

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.81
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) nucleus (CRX)
response to stress (Crh) cytoplasm (Crh)
Anatomy Link Frequency
CeA 2
visceral 1
spinal cord 1
CRX (Homo sapiens)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 68 100.00 Very High Very High Very High
Visceral pain 18 99.64 Very High Very High Very High
Spinal cord 12 98.32 Very High Very High Very High
anesthesia 20 97.16 Very High Very High Very High
Pain 18 94.24 High High
Dorsal horn 4 89.04 High High
imagery 2 74.96 Quite High
Thalamus 2 68.00 Quite High
Hippocampus 2 65.92 Quite High
cerebral cortex 4 53.36 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

48 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

18 99.64 Very High Very High Very High
Pain 22 94.24 High High
Anxiety Disorder 16 90.24 High High
Unconsciousness 8 80.80 Quite High
Stress 12 72.24 Quite High
Nociception 8 5.00 Very Low Very Low Very Low
Depression 8 5.00 Very Low Very Low Very Low
Post-traumatic Stress Disorder 6 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The main result of this study is that the expression of CRF and pERK in the CeA was significantly increased by CRD-induced visceral pain, and that this effect was attenuated by general anesthesia, whereas the expression of c-Fos in the spinal cord was unaffected by general anesthesia.
CRD Positive_regulation (increased) of in spinal cord Gene_expression (expression) of CRF in visceral associated with anesthesia, visceral pain, amygdala and spinal cord
1) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967003 Disease Relevance 0.15 Pain Relevance 0.90
CRD elicited a significant increase in the expression of CRF and p-ERK in the CeA and of c-Fos in the spinal cord.
CRD Positive_regulation (elicited) of Gene_expression (expression) of CRF in CeA associated with amygdala and spinal cord
2) Confidence 0.04 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2967003 Disease Relevance 0.34 Pain Relevance 0.80

General Comments

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