INT34139

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Context Info
Confidence 0.28
First Reported 1986
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.40
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Nrd1) mitochondrion (Nrd1)
Anatomy Link Frequency
spinal cord 1
brains 1
Nrd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 7 100.00 Very High Very High Very High
Spinal cord 1 99.68 Very High Very High Very High
Analgesic 4 97.60 Very High Very High Very High
Lasting pain 1 96.56 Very High Very High Very High
narcan 3 95.12 Very High Very High Very High
tail-flick 1 85.72 High High
Central nervous system 1 83.92 Quite High
intrathecal 1 82.36 Quite High
analgesia 1 77.56 Quite High
Endogenous opioid 1 76.56 Quite High
Disease Link Frequency Relevance Heat
Pain 1 96.56 Very High Very High Very High
Convulsion 1 80.92 Quite High
Postmortem Changes 1 75.00 Quite High
Sprains And Strains 1 74.56 Quite High
Autolysis 1 70.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 3H-GEMSA binding to enkephalin convertase in the spinal cord of these rats produced only a slight increase in KD; besides, no changes in the enzyme activity were observed.
convertase Binding (binding) of in spinal cord associated with enkephalin and spinal cord
1) Confidence 0.28 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3102992 Disease Relevance 0.18 Pain Relevance 1.17
Mg-ATPase activity was reduced in brains kept at 25 degrees C for 24 and 48 h. [3H]Guanidinoethylmercaptosuccinic acid [( 3H]GEMSA) binding to enkephalin convertase in the cytosol was not significantly changed in brains kept at 25 degrees C; however, a small increase was seen for [3H]GEMSA binding to the membrane fraction at 24, but not 48 and 72 h postmortem. [3H]Quinuclidinyl benzilate [( 3H]QNB) binding to muscarinic cholinergic receptors decreased in brains kept at 25 degrees C for 72 h.
convertase Binding (binding) of in brains associated with enkephalin
2) Confidence 0.05 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3029332 Disease Relevance 0.22 Pain Relevance 0.23

General Comments

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