INT34140

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Context Info
Confidence 0.10
First Reported 1987
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.23
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Vcp) endoplasmic reticulum (Vcp) protein complex (Vcp)
cytoplasm (Vcp) cytosol (Vcp) lipid binding (Vcp)
Anatomy Link Frequency
blood 2
brains 1
Vcp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 16 97.94 Very High Very High Very High
Enkephalin 2 95.48 Very High Very High Very High
opioid receptor 1 62.64 Quite High
Delta opioid receptors 1 52.64 Quite High
narcan 2 37.68 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 1 79.84 Quite High
Autolysis 1 75.80 Quite High
Postmortem Changes 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mg-ATPase activity was reduced in brains kept at 25 degrees C for 24 and 48 h. [3H]Guanidinoethylmercaptosuccinic acid [( 3H]GEMSA) binding to enkephalin convertase in the cytosol was not significantly changed in brains kept at 25 degrees C; however, a small increase was seen for [3H]GEMSA binding to the membrane fraction at 24, but not 48 and 72 h postmortem. [3H]Quinuclidinyl benzilate [( 3H]QNB) binding to muscarinic cholinergic receptors decreased in brains kept at 25 degrees C for 72 h.
Negative_regulation (reduced) of Mg-ATPase in brains associated with enkephalin
1) Confidence 0.10 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3029332 Disease Relevance 0.23 Pain Relevance 0.21
Effects of functional ablation of peptidergic sensory nerves with neurotoxic doses of capsaicin (150 mg/kg, s/c) as well as of their stimulation with small doses of capsaicin (5 mg/kg, i/p) on activity of proteinase inhibitors: alpha1-antitrypsin (alpha1-AT)-serine proteinase inhibitor and alpha2-macroglobulin (alpha2-MG)-nonspecific inhibitor were investigated in rat blood.
Negative_regulation (inhibitor) of alpha2-MG in blood associated with qutenza
2) Confidence 0.02 Published 2006 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 17290875 Disease Relevance 0 Pain Relevance 0.56
Effects of functional ablation of peptidergic sensory nerves with neurotoxic doses of capsaicin (150 mg/kg, s/c) as well as of their stimulation with small doses of capsaicin (5 mg/kg, i/p) on activity of proteinase inhibitors: alpha1-antitrypsin (alpha1-AT)-serine proteinase inhibitor and alpha2-macroglobulin (alpha2-MG)-nonspecific inhibitor were investigated in rat blood.
Negative_regulation (inhibitor) of alpha2-MG in blood associated with qutenza
3) Confidence 0.02 Published 2006 Journal Ross Fiziol Zh Im I M Sechenova Section Abstract Doc Link 17290875 Disease Relevance 0 Pain Relevance 0.55

General Comments

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