INT34141

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Context Info
Confidence 0.50
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.38
Pain Relevance 1.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IMPA1) mitochondrion (IMPA1) nucleolus (IMPA1)
nucleus (IMPA1) cytoplasm (IMPA1)
Anatomy Link Frequency
muscle 2
CSF 1
synovium 1
lung 1
IMPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 2 99.68 Very High Very High Very High
Pain 6 98.12 Very High Very High Very High
fibrosis 6 97.12 Very High Very High Very High
anesthesia 10 93.68 High High
Inflammation 26 91.48 High High
Acute pain 2 91.36 High High
tricyclic antidepressant 1 82.52 Quite High
imagery 5 76.72 Quite High
antidepressant 2 75.00 Quite High
backache 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 25 100.00 Very High Very High Very High
Pain 7 99.68 Very High Very High Very High
Syndrome 1 98.36 Very High Very High Very High
Infection 4 97.80 Very High Very High Very High
Fibrosis 8 97.12 Very High Very High Very High
INFLAMMATION 28 91.48 High High
Hypersensitivity 1 90.32 High High
Congenital Anomalies 11 87.44 High High
Mitral Valve Insufficiency 20 86.48 High High
Coronary Heart Disease 14 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IMP was increased as compared to baseline (Figure 1) due to insignificant prolongation of IRT (p = 0.18), prolongation of ICT, and LVET shortening.
Positive_regulation (increased) of IMP
1) Confidence 0.50 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.32 Pain Relevance 0.05
The finding of a lack of IMP accumulation or ATP decrease during exercise in the present study is consistent with other studies showing that no changes in muscle IMP, ATP or NH3 occur until PCr levels have significantly decreased to values below ?
Positive_regulation (accumulation) of IMP in muscle
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957441 Disease Relevance 0.12 Pain Relevance 0
The IMP can be calculated as
Positive_regulation (calculated) of IMP
3) Confidence 0.36 Published 2006 Journal Cardiovasc Ultrasound Section Body Doc Link PMC1654186 Disease Relevance 0.08 Pain Relevance 0
The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05).
Positive_regulation (increased) of IMP in CSF associated with pain and lasting pain
4) Confidence 0.25 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20211694 Disease Relevance 0.74 Pain Relevance 0.64
In rats, preloading doses of imipramine depressed lung uptake but did not result in increased brain IMP uptake; postloading doses of imipramine did not release IMP from the lung.
Neg (not) Positive_regulation (increased) of IMP in lung
5) Confidence 0.24 Published 1987 Journal J. Nucl. Med. Section Abstract Doc Link 3029345 Disease Relevance 0 Pain Relevance 0.30
On application of deep muscle retraction, there was a rapid and sustained increase in IMP (P < 0.001), and overall, the calculated mean IPP approached 0 mm Hg or less during this period (P < 0.001).
Positive_regulation (increase) of IMP in muscle
6) Confidence 0.18 Published 2004 Journal Neurosurgery Section Body Doc Link 15157298 Disease Relevance 0.07 Pain Relevance 0
(Anaplasma spp.) were reported as a cause of type II IMPA in dogs [13] where it is assumed that the infectious process provides an antigenic source for immune complex formation, and either the antigen or circulating complexes are deposited within the synovium to initiate inflammation by a type III hypersensitivity reaction [14].
Positive_regulation (cause) of IMPA in synovium associated with inflammation, hypersensitivity and arthritis
7) Confidence 0.05 Published 2006 Journal Acta Vet Scand Section Body Doc Link PMC1553462 Disease Relevance 0.88 Pain Relevance 0.14
In 20 HT adult recipients with grade 3A cellular rejection, there was a mean increase of IMP by 98% (p < 0.0001) during the AAR episode and a decrease to its baseline values after treatment; in addition, the change in IMP was independent of both baseline EF and EF changes during AAR [23].
Positive_regulation (increase) of IMP
8) Confidence 0.03 Published 2008 Journal Cardiovasc Ultrasound Section Body Doc Link PMC2249582 Disease Relevance 0.17 Pain Relevance 0

General Comments

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