INT341427

Context Info Confidence 0.52 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.36 Pain Relevance 0.48

extracellular region (EPO, BDNF) signal transduction (EPO) extracellular space (EPO) aging (EPO) cytoplasmic membrane-bounded vesicle (BDNF)

Anatomy Link Frequency nerve 1 EPO (Homo sapiens) BDNF (Homo sapiens)

Pain Link Frequency Relevance Heat Nerve growth factor 3 99.80 Inflammation 2 98.24 antidepressant 24 94.00 Hippocampus 2 89.52 imagery 6 85.24 Inflammatory marker 2 78.48 depression 24 50.00 Multiple sclerosis 2 5.00 Spinal cord 1 5.00 ischemia 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 4 98.24 Cognitive Disorder 26 70.84 Attention Deficit Hyperactivity Disorder 7 62.48 Obesity 1 54.16 Depression 22 50.00 Affective Disorder 15 45.60 Disorder Of Lipid Metabolism 1 34.08 Manic Depressive Disorder 16 5.00 Aplasia 6 5.00 Hypertension 4 5.00

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Protein

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Anatomy

Negation

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It is known that Epo increase hippocampal BDNF and nerve growth factor (NGF) and has anti-inflammatory actions, but it is unclear whether these actions are mechanistically important for potential antidepressant effects of Epo.

Epo Positive_regulation (increase) of BDNF in nerve associated with antidepressant, inflammation and nerve growth factor

1) Confidence 0.52 Published 2010 Journal Trials Section Body Doc Link PMC2967509 Disease Relevance 0.36 Pain Relevance 0.48

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