INT341470

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 6.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

H19 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 7 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 483 99.24 Very High Very High Very High
Pancreatic Cancer 224 98.72 Very High Very High Very High
Disease 21 94.88 High High
Metastasis 119 90.20 High High
Starvation 14 83.96 Quite High
Hypoxia 28 83.00 Quite High
Pancreatic Ductal Carcinoma 14 82.36 Quite High
Diphtheria 28 80.08 Quite High
Bladder Cancer 14 75.56 Quite High
Adenocarcinoma 21 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous H19 regulatory sequence activity was assayed by expressing the luciferase gene under the control of H19 regulatory sequences (Luc-H19 plasmid).
Regulation (control) of H19
1) Confidence 0.44 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.40 Pain Relevance 0
We demonstrated that although the treatment consisted of an injection of naked DNA into the tumor, the vector indeed entered the cells and the H19 sequence was effective in leading to the DT-A gene expression (Figure 7).
Regulation (effective) of H19 associated with cancer
2) Confidence 0.44 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.13 Pain Relevance 0
The results showed that the DTA-H19 vector was effective in reducing the Luciferase activity in all the cell lines and that there is a dose-response effect (Figure 3).
Regulation (effective) of H19
3) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.33 Pain Relevance 0
As expected, DTA-H19 treatment was effective in inhibiting the tumor growth compared with the Luc-H19 treated tumors.
Regulation (effective) of H19 associated with cancer
4) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.42 Pain Relevance 0
H19 promoter activity was analyzed in all human and hamster cell lines using a plasmid carrying the luciferase gene under the control of H19 regulatory sequence.
Regulation (control) of H19
5) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.99 Pain Relevance 0
Intratumoral injection of the toxin vector under the control of the H19 regulatory sequences induced a 50% decrease in the median tumor volume as compared to that of the tumor treated with the Luc-H19 vector (Figures 6(b) and 6(c)).
Regulation (control) of H19 associated with cancer
6) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 1.25 Pain Relevance 0
The presented results lead us to advocate a new DNA-based treatment for pancreatic cancer, inducing cytotoxic effect in cancer cells by intratumoral injection of a naked DNA vector containing the DT-A gene under the control of H19 regulatory sequences for human pancreatic cancer.


Regulation (control) of H19 associated with cancer and pancreatic cancer
7) Confidence 0.38 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2967839 Disease Relevance 0.92 Pain Relevance 0

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