INT341481

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Context Info
Confidence 0.28
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.47
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SCN8A) transmembrane transport (SCN8A)
SCN8A (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 33 93.44 High High
Hyperalgesia 1 87.44 High High
sodium channel 5 86.76 High High
Nav1.7 3 83.04 Quite High
tetrodotoxin 2 82.24 Quite High
nav1.8 1 76.72 Quite High
Inflammation 3 73.40 Quite High
Peripheral nervous system 2 70.56 Quite High
Neuropathic pain 4 55.20 Quite High
Paroxysmal extreme pain disorder 6 30.00 Quite Low
Disease Link Frequency Relevance Heat
Frailty 1 99.32 Very High Very High Very High
Ataxia 1 98.84 Very High Very High Very High
Heart Arrhythmia 1 98.26 Very High Very High Very High
Hypopituitarism 1 97.12 Very High Very High Very High
Epilepsy 1 96.42 Very High Very High Very High
Pain 50 93.44 High High
Hyperalgesia 1 87.44 High High
Neuropathic Pain 5 74.80 Quite High
INFLAMMATION 3 73.40 Quite High
Hypersensitivity 1 63.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of SCN1A and SCN2A [3] genes have been associated with epilepsy, SCN4A is associated with myotonia disorders [4], SCN5A is associated with Brugada syndrome (OMIM 601144) [5], which is characterized by cardiac arrhythmias in young people, and SCN8A is associated with cerebellar atrophy and ataxia [6].
SCN8A Binding (associated) of associated with epilepsy, ataxia, frailty, heart arrhythmia and hypopituitarism
1) Confidence 0.28 Published 2010 Journal Dermatology (Basel, Switzerland) Section Body Doc Link PMC2969160 Disease Relevance 1.47 Pain Relevance 1.23

General Comments

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