INT341506

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
TLR2 (Homo sapiens)
Pdcd1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 7 56.80 Quite High
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diffuse Cutaneous Leishmaniasis 74 99.20 Very High Very High Very High
Infection 18 99.06 Very High Very High Very High
Disease 12 93.44 High High
Leishmaniasis 50 21.52 Low Low
Apoptosis 17 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Viral Infection 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Chronic Disease 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It remains to be determined if the exhausted condition of CD8 towards parasite antigens is a cause or a consequence of the progressive infection of DCL patients by Leishmania mexicana and if TLR2 induces downregulation of PD-1 pathway.
TLR2 Positive_regulation (induces) of Negative_regulation (downregulation) of PD-1 associated with diffuse cutaneous leishmaniasis and infection
1) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.54 Pain Relevance 0.03

General Comments

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