INT341540

Context Info Confidence 0.18 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.51 Pain Relevance 0

Golgi apparatus (F2RL1) plasma membrane (F2RL1) signal transducer activity (F2RL1)

Anatomy Link Frequency kidney 3 F2RL1 (Homo sapiens) AREG (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 26 24.24 Inflammation 35 9.52 Arthritis 5 5.00 Inflammatory mediators 4 5.00 antagonist 4 5.00 cytokine 3 5.00 Inflammatory response 3 5.00 COX2 1 5.00 spastic colon 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Chronic Obstructive Pulmonary Disease 2 98.24 Cancer 20 89.04 Metastasis 4 88.16 Carcinoma 1 61.52 Targeted Disruption 2 32.76 Breast Cancer 1 32.48 INFLAMMATION 42 9.52 Arthritis 5 5.00 Disease 5 5.00 Adhesions 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our array data has demonstrated that amphiregulin expression is also substantially induced in kidney cells by PAR2 activation and this may be important in proliferation of kidney cells.

Positive_regulation (activation) of PAR2 in kidney Positive_regulation (induced) of Gene_expression (expression) of amphiregulin in kidney

1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.51 Pain Relevance 0

General Comments

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