INT341570

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCNA1) nucleoplasm (CCNA1) mitosis (CCNA1)
nucleus (CCNA1) cell division (CCNA1)
Anatomy Link Frequency
neuronal 1
CCNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 26 85.28 High High
Hippocampus 8 76.12 Quite High
Pyramidal cell 1 7.24 Low Low
Inflammation 35 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 5 98.96 Very High Very High Very High
Ataxia 3 96.52 Very High Very High Very High
Polyploidy 5 92.84 High High
Supranuclear Palsy 1 86.88 High High
Dementia 4 83.92 Quite High
Cancer 21 83.76 Quite High
Disease 117 81.20 Quite High
Hyperplasia 1 77.12 Quite High
Stress 7 70.40 Quite High
Tremor 1 29.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, this PSP case also had the highest percentage of CDN stained with cyclin A, a robust presence of the PHF-1 tau epitope, an increase in staining for the cell death marker, cleaved caspase 6, and a clear reduction of neuronal density (Figure 5).
Spec (clear) Positive_regulation (increase) of cyclin A in neuronal associated with death
1) Confidence 0.45 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC3018387 Disease Relevance 0.85 Pain Relevance 0.04
CCNA1 and CCNYL1 were upregulated 2 and 1.5 fold respectively, and expression of CCNF, CDK5 and CDK10 were suppressed, up to 2 fold for CDK10.
Positive_regulation (upregulated) of CCNA1
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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