INT341594

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ESR1, HLA-B) nucleoplasm (ESR1) enzyme binding (ESR1)
DNA binding (ESR1) protein complex (ESR1) cytoplasm (ESR1)
Anatomy Link Frequency
reticulum 1
ESR1 (Homo sapiens)
HLA-B (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 38 100.00 Very High Very High Very High
Crohn's disease 27 71.16 Quite High
Inflammation 5 5.00 Very Low Very Low Very Low
spondylitis 2 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Low Back Pain 40 100.00 Very High Very High Very High
Disease 39 71.16 Quite High
Asthma 3 57.80 Quite High
Diabetes Mellitus 2 49.36 Quite Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Spondylarthritis 3 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 3 5.00 Very Low Very Low Very Low
Psoriasis 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HLA-B27, a well-known risk factor associated with AS, has the tendency to misfold during class I complex formation in the endoplasmic reticulum (ER).
ER Binding (formation) of HLA-B27 in reticulum associated with spinal inflammation
1) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970560 Disease Relevance 0.72 Pain Relevance 0.57

General Comments

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