INT341625

Context Info Confidence 0.41 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.22 Pain Relevance 0.46

peptidase activity (CTRC) extracellular region (SPINK1)

SPINK1 (Homo sapiens) CTRC (Homo sapiens)

Pain Link Frequency Relevance Heat fibrosis 1 100.00 Chronic pancreatitis 5 99.70 abdominal pain 7 55.92 imagery 3 5.00 nud 2 5.00 Pain 1 5.00

Disease Link Frequency Relevance Heat Cystic Fibrosis 1 100.00 Pancreatitis 38 99.70 Pancreatic Cancer 1 80.20 Disease 5 64.84 Emergencies 1 59.20 Abdominal Pain 7 55.92 Vomiting 1 54.00 Fever 1 52.72 Body Weight 3 5.00 Dyspepsia 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Chronic pancreatitis has also been associated with mutations in other genes such as SPINK 1 (serine protease inhibitor Kazal Type I) [7], CFTR (Cystic Fibrosis transmembrane conductance regulator) [8], CTRC (chymotrypsin C) [9].

SPINK 1 Binding (associated) of chymotrypsin C associated with fibrosis, cystic fibrosis and chronic pancreatitis

1) Confidence 0.41 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2970583 Disease Relevance 1.22 Pain Relevance 0.46

General Comments

This test has worked.