INT341655

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.48
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGA) extracellular space (FGA) extracellular region (FGA)
plasma membrane (FGA) protein binding, bridging (FGA)
Anatomy Link Frequency
urine 2
plasma 1
hepatocytes 1
megakaryocytes 1
FGA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 217 95.76 Very High Very High Very High
rheumatoid arthritis 56 90.32 High High
cytokine 35 89.40 High High
methotrexate 7 84.08 Quite High
Arthritis 259 80.08 Quite High
Inflammatory mediators 21 78.68 Quite High
Analgesic 7 38.68 Quite Low
chemokine 21 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 35 99.96 Very High Very High Very High
Disease 441 98.20 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 350 97.92 Very High Very High Very High
INFLAMMATION 245 95.76 Very High Very High Very High
Infection 35 91.80 High High
Rheumatoid Arthritis 56 90.32 High High
Arthritis 238 80.08 Quite High
Renal Disease 28 64.00 Quite High
Fever 77 52.56 Quite High
Amyloidosis 14 51.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Urinary peptide FGA (607–622) 1,639.77, and FGA (605–622) 1,883.80 were not detected in either our analysis or the previously published one [38].
Neg (not) Gene_expression (detected) of FGA
1) Confidence 0.56 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.16 Pain Relevance 0.03
Urinary peptide FGA (607–622) 1,639.77, and FGA (605–622) 1,883.80 were not detected in either our analysis or the previously published one [38].
Neg (not) Gene_expression (detected) of FGA
2) Confidence 0.56 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.16 Pain Relevance 0.03
Such differences may explain the differences in expression of the FGA peptide biomarkers in urine between SJIA flare and Kawasaki disease.
Gene_expression (expression) of FGA in urine associated with mucocutaneous lymph node syndrome
3) Confidence 0.56 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.85 Pain Relevance 0.34
Future prospective studies are needed to determine whether the plasma A1AT, FGA, and FGB peptides have diagnostic or prognostic value in SJIA disease management.
Gene_expression (peptides) of FGA in plasma associated with alpha-1-antitrypsin deficiency and disease
4) Confidence 0.56 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.79 Pain Relevance 0.11
Given that fibrinogen is a substrate of MMP9 [39–41], it is possible that up regulation of MMP9 and TIMP1 in circulation may be directly associated to the generation of FGA peptide biomarkers that ultimately are enriched in urine during active SJIA.
Gene_expression (generation) of FGA in urine
5) Confidence 0.44 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.58 Pain Relevance 0.19
For example, A1AT, FGA, and FGB are all acute-phase plasma proteins, which are synthesized by hepatocytes and megakaryocytes [45] and are found at high levels in the circulation in the setting of acute or chronic inflammation.
Gene_expression (synthesized) of FGA in hepatocytes associated with alpha-1-antitrypsin deficiency and inflammation
6) Confidence 0.44 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.97 Pain Relevance 0.19
For example, A1AT, FGA, and FGB are all acute-phase plasma proteins, which are synthesized by hepatocytes and megakaryocytes [45] and are found at high levels in the circulation in the setting of acute or chronic inflammation.
Gene_expression (synthesized) of FGA in megakaryocytes associated with alpha-1-antitrypsin deficiency and inflammation
7) Confidence 0.15 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.97 Pain Relevance 0.19

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