INT341658

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.91
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (TIMP1) extracellular region (TIMP1)
Anatomy Link Frequency
T cell 2
TIMP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1 100.00 Very High Very High Very High
Inflammation 31 78.20 Quite High
Arthritis 37 52.04 Quite High
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 63 94.68 High High
Mucocutaneous Lymph Node Syndrome 50 88.76 High High
INFLAMMATION 35 78.20 Quite High
Fever 11 69.76 Quite High
Juvenile Chronic Polyarthritis 3 52.04 Quite High
Arthritis 34 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low
Alpha-1-antitrypsin Deficiency 5 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low
Renal Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Negative_regulation (inhibitor) of Regulation (regulated) of metalloproteinase-1 in T cell associated with metalloproteinase
1) Confidence 0.33 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.91 Pain Relevance 0.21

General Comments

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