INT341662

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Context Info
Confidence 0.48
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 3.06
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGB) extracellular space (FGB) extracellular region (FGB)
plasma membrane (FGB) protein binding, bridging (FGB)
Anatomy Link Frequency
plasma 2
hepatocytes 1
megakaryocytes 1
FGB (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 124 96.56 Very High Very High Very High
Arthritis 148 80.08 Quite High
Inflammatory mediators 12 78.32 Quite High
rheumatoid arthritis 32 42.40 Quite Low
Analgesic 4 22.88 Low Low
chemokine 12 13.76 Low Low
cytokine 20 12.56 Low Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alpha-1-antitrypsin Deficiency 20 99.78 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 200 98.52 Very High Very High Very High
Disease 252 98.20 Very High Very High Very High
INFLAMMATION 140 96.56 Very High Very High Very High
Infection 20 91.44 High High
Arthritis 136 80.08 Quite High
Renal Disease 16 64.00 Quite High
Amyloidosis 8 51.28 Quite High
Rheumatoid Arthritis 32 42.40 Quite Low
Membranous Glomerulonephritis 4 33.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, A1AT, FGA, and FGB are all acute-phase plasma proteins, which are synthesized by hepatocytes and megakaryocytes [45] and are found at high levels in the circulation in the setting of acute or chronic inflammation.
Gene_expression (synthesized) of FGB in hepatocytes associated with alpha-1-antitrypsin deficiency and inflammation
1) Confidence 0.48 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.97 Pain Relevance 0.19
A urinary FGB peptide found in SJIA (at similar levels in KD, but not comparison groups with less systemic inflammation) is identical to a peptide found in normal plasma, suggesting that the precursor protein is increased during inflammation.
Gene_expression (peptide) of FGB in plasma associated with mucocutaneous lymph node syndrome and inflammation
2) Confidence 0.47 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.34 Pain Relevance 0.12
Future prospective studies are needed to determine whether the plasma A1AT, FGA, and FGB peptides have diagnostic or prognostic value in SJIA disease management.
Spec (whether) Gene_expression (peptides) of FGB in plasma associated with alpha-1-antitrypsin deficiency and disease
3) Confidence 0.47 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.78 Pain Relevance 0.11
For example, A1AT, FGA, and FGB are all acute-phase plasma proteins, which are synthesized by hepatocytes and megakaryocytes [45] and are found at high levels in the circulation in the setting of acute or chronic inflammation.
Gene_expression (synthesized) of FGB in megakaryocytes associated with alpha-1-antitrypsin deficiency and inflammation
4) Confidence 0.16 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.97 Pain Relevance 0.19

General Comments

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