INT341666

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.05
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ENPEP) peptidase activity (ENPEP) plasma membrane (ALPI)
cell-cell signaling (ENPEP)
Anatomy Link Frequency
osteoblast 1
ALPI (Homo sapiens)
ENPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 24.24 Low Low
Pain 1 20.08 Low Low
dexamethasone 7 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 22 99.08 Very High Very High Very High
Osteoporosis 46 98.56 Very High Very High Very High
Osteolysis 7 82.48 Quite High
Hypercalcemia 9 65.92 Quite High
Bone Cancer 2 53.24 Quite High
Apoptosis 1 50.56 Quite High
Spinal Cord Compression 2 24.72 Low Low
Pain 1 20.08 Low Low
Malignant Neoplastic Disease 1 14.04 Low Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evidence suggesting that bortezomib, the first clinically available proteasome inhibitor, could overcome the osteoblast inhibition observed in MM was provided from the APEX trial where serum alkaline phosphatase (AP) was found to be increased in patients responding to bortezomib treatment (21).
alkaline phosphatase Positive_regulation (increased) of AP in osteoblast associated with osteoporosis and multiple myeloma
1) Confidence 0.01 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 1.05 Pain Relevance 0

General Comments

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