INT341779

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DBT, PRKCA) small molecule metabolic process (DBT, PRKCA) cytoplasm (DBT, PRKCA)
nucleoplasm (PRKCA) endoplasmic reticulum (PRKCA) enzyme binding (PRKCA)
DBT (Homo sapiens)
PRKCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 12 99.68 Very High Very High Very High
Neurotransmitter 11 94.08 High High
cocaine 2 67.92 Quite High
depression 8 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
sSRI 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
amygdala 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 50.00 Quite Low
Mental Disorders 3 50.00 Quite Low
Targeted Disruption 1 48.08 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Post-partum Depression 3 5.00 Very Low Very Low Very Low
Endometriosis (extended) 3 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We recently determined that E2 can rapidly alter several signaling pathways in PC12 cells to cause efflux of dopamine via the DAT;58 PKC and MEK (the enzyme upstream of the MAPK-ERKs) are activated by E2.
E2 Positive_regulation (activated) of PKC associated with dopamine
1) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0 Pain Relevance 0.22

General Comments

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