INT341816

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.76
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (CEP68) cytoplasm (CEP68)
CEP68 (Homo sapiens)
Aia1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 312 99.30 Very High Very High Very High
Inflammation 30 14.96 Low Low
cINOD 30 5.00 Very Low Very Low Very Low
Analgesic 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 546 100.00 Very High Very High Very High
Obesity 24 99.08 Very High Very High Very High
Nicotine Addiction 12 98.16 Very High Very High Very High
Hypersensitivity 60 95.44 Very High Very High Very High
Occupational Lung Diseases 84 94.16 High High
Respiratory Disease 6 85.96 High High
Disease 54 84.36 Quite High
INFLAMMATION 42 14.96 Low Low
Bronchospasm 12 5.00 Very Low Very Low Very Low
Respiratory Sounds 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the significant association of haplotype CEP68_ht4 with AIA, the LD of CEP68 might facilitate mapping out genetic factors that function in aspirin metabolism and/or aspirin hypersensitivity in asthma.
CEP68_ht4 Spec (might) Binding (association) of AIA associated with asthma, aspirin and hypersensitivity
1) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.81 Pain Relevance 0.13
0.81; Table 3), it is considered that haplotype CEP68_ht4, which includes most minor alleles of the significantly associated SNPs and the major G allele of rs10496123G>A, may mainly affect the association with AIA.
CEP68_ht4 Binding (association) of AIA associated with asthma
2) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 1.08 Pain Relevance 0.11
In addition, with a tight LD among the SNPs of the CEP68 gene, the haplotype CEP68_ht4 (T-G-A-A-A-C-G) in AIA subjects was more frequent when compared to that of ATA controls and was significantly associated with AIA.
CEP68_ht4 Binding (associated) of AIA associated with asthma
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.86 Pain Relevance 0.07
After haplotypes were inferred using PHASE software, results from logistic analyses for associations between haplotypes and aspirin intolerance showed that haplotype CEP68_ht4 (T-G-A-A-A-C-G) of AIA was more frequent than that of ATA as a control group, showing that the CEP68_ht4 with the nonsynonymous rs7572857 “A” allele at the fourth position was significantly associated with AIA in both the co-dominant (OR ?
CEP68_ht4 Binding (associated) of AIA associated with asthma and aspirin
4) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.54 Pain Relevance 0.16
After haplotypes were inferred using PHASE software, results from logistic analyses for associations between haplotypes and aspirin intolerance showed that haplotype CEP68_ht4 (T-G-A-A-A-C-G) of AIA was more frequent than that of ATA as a control group, showing that the CEP68_ht4 with the nonsynonymous rs7572857 “A” allele at the fourth position was significantly associated with AIA in both the co-dominant (OR ?
CEP68_ht4 Binding (associated) of AIA associated with asthma and aspirin
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.56 Pain Relevance 0.17
Polymorphisms of the CEP68 gene showed the most significant association with AIA compared to ATA controls in co-dominant model (Table 3, P?
CEP68 Binding (association) of AIA associated with asthma
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972220 Disease Relevance 0.91 Pain Relevance 0.12

General Comments

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