INT341847

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ERBB2) signal transduction (ERBB2) plasma membrane (ERBB2)
nucleus (ERBB2) cytoplasm (ERBB2)
ERBB2 (Homo sapiens)
ESYT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 2 63.48 Quite High
methotrexate 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Advanced Or Metastatic Breast Cancer 124 100.00 Very High Very High Very High
Vomiting 10 94.16 High High
Exanthema 14 93.44 High High
Diarrhoea 20 92.96 High High
Cancer 98 87.08 High High
Breast Cancer 92 86.20 High High
Disease 48 77.92 Quite High
Cardiovascular Disorder Under Development 4 69.40 Quite High
Metastasis 18 63.92 Quite High
Syndrome 8 58.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The large, ongoing Aphrodite trial has a target population of 8,000 patients with HER2-overexpressed MBC.
HER2 Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MBC associated with advanced or metastatic breast cancer
1) Confidence 0.02 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.58 Pain Relevance 0.03
In this group of heavily pretreated patients (76% of whom received four or more lines of prior therapy), lapatinib had modest activity in HER2-overexpressed MBC.
HER2 Positive_regulation (overexpressed) of Gene_expression (-) of MBC associated with advanced or metastatic breast cancer
2) Confidence 0.02 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.84 Pain Relevance 0

General Comments

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