INT341851

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MED1) small molecule metabolic process (MED1) cell morphogenesis (MED1)
nucleolus (MED1) nucleus (MED1) DNA binding (MED1)
MED1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 46 88.96 High High
Cancer 49 88.48 High High
Toxicity 33 77.64 Quite High
Disease 24 72.16 Quite High
Hyperplasia 2 62.00 Quite High
Apoptosis 3 60.52 Quite High
Advanced Or Metastatic Breast Cancer 62 50.00 Quite Low
Solid Tumor 11 5.00 Very Low Very Low Very Low
Diarrhoea 10 5.00 Very Low Very Low Very Low
Metastasis 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gefitinib has been shown to block EGFR downstream signal transduction pathways; this induces cell cycle arrest, which leads to accumulation of the cyclin-dependent kinase 2 inhibitor p27KIP1 and marked accumulation of hypophosphorylated Rb protein, which leads to G1 arrest [40].
Positive_regulation (accumulation) of Rb protein
1) Confidence 0.01 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.50 Pain Relevance 0

General Comments

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