INT341853

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.85
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1 89.44 High High
headache 1 5.36 Low Low
methotrexate 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Breast Neoplasms 1 90.00 High High
Breast Cancer 46 88.32 High High
Metastasis 9 87.64 High High
Cancer 49 76.00 Quite High
Colon Cancer 2 55.64 Quite High
Toxicity 33 53.68 Quite High
Vomiting 5 51.28 Quite High
Fatigue 2 50.76 Quite High
Advanced Or Metastatic Breast Cancer 62 50.00 Quite Low
Dizziness 1 48.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several compounds in preclinical and clinical trials have targeted various stages of the Ras signaling cascade, including inhibition of Ras expression via antisense oligo-deoxynucleotides, interference via farnesyltransferase inhibitors, and inhibition of Ras downstream effectors via MEK, PI3K inhibitors, and others.
Negative_regulation (inhibition) of Negative_regulation (inhibitors) of PI3K
1) Confidence 0.14 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.85 Pain Relevance 0.04

General Comments

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