INT341895

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.49
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Oxt, POMC) extracellular space (Oxt, POMC) extracellular region (Oxt, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Oxt)
Anatomy Link Frequency
external 2
anterior pituitary 2
Oxt (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 96 96.16 Very High Very High Very High
Neuropeptide 24 65.68 Quite High
Intracerebroventricular 8 36.48 Quite Low
antagonist 152 5.00 Very Low Very Low Very Low
Spinal cord 32 5.00 Very Low Very Low Very Low
Antinociceptive 32 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
Glutamate 16 5.00 Very Low Very Low Very Low
Dorsal horn 16 5.00 Very Low Very Low Very Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 97.68 Very High Very High Very High
Wound Healing 4 54.60 Quite High
Injury 4 48.36 Quite Low
Anxiety Disorder 32 40.84 Quite Low
Intellectual Impairment 8 37.80 Quite Low
Obsessive-compulsive Disorder 4 34.40 Quite Low
Autism 24 32.72 Quite Low
Cognitive Disorder 12 22.48 Low Low
Targeted Disruption 40 5.00 Very Low Very Low Very Low
Pain 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the early 1990s, Dayanithi's group first demonstrated that oxytocin alone at physiological concentrations (already at 1 nM) under normal conditions, applied in a pulsatile fashion, induces the release of ACTH in freshly isolated rat anterior pituitary cells [54].
oxytocin Positive_regulation (induces) of Localization (release) of ACTH in anterior pituitary
1) Confidence 0.08 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.14 Pain Relevance 0.03
Furthermore, this ACTH release induced by oxytocin is blocked by glucocorticoids (corticosterone or RU 28362, a selective glucocorticoid receptor agonist) without interfering with [Ca2+]i transients [57].
oxytocin Positive_regulation (induced) of Localization (release) of ACTH associated with agonist
2) Confidence 0.06 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.06 Pain Relevance 0.05
Oxytocin-dependent stimulation of ACTH release is mediated by an increase in [Ca2+]i, which occurs in the absence of external Ca2+[54,56] by mobilizing Ca2+ from InsP3-sensitive intracellular Ca2+ stores [57].
Oxytocin Positive_regulation (stimulation) of Localization (release) of ACTH in external
3) Confidence 0.06 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.07 Pain Relevance 0.04
In addition to CRH and vasopressin, the oxytocin-induced ACTH secretion is suppressed by adrenal glucocorticoid hormones, and hence oxytocin is considered to be a hypophysiotrophic hormone.
oxytocin Positive_regulation (induced) of Localization (secretion) of ACTH
4) Confidence 0.06 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.22 Pain Relevance 0.03

General Comments

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