INT341896

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.91
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Oxt, POMC) extracellular space (Oxt, POMC) extracellular region (Oxt, POMC)
small molecule metabolic process (POMC) cell-cell signaling (POMC) response to stress (Oxt)
Anatomy Link Frequency
corticotrophs 4
Oxt (Rattus norvegicus)
POMC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 96 94.28 High High
Neuropeptide 24 77.88 Quite High
Intracerebroventricular 8 59.04 Quite High
antagonist 152 5.00 Very Low Very Low Very Low
Spinal cord 32 5.00 Very Low Very Low Very Low
Antinociceptive 32 5.00 Very Low Very Low Very Low
amygdala 16 5.00 Very Low Very Low Very Low
Glutamate 16 5.00 Very Low Very Low Very Low
Dorsal horn 16 5.00 Very Low Very Low Very Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 48 99.72 Very High Very High Very High
Wound Healing 4 66.80 Quite High
Injury 4 60.56 Quite High
Anxiety Disorder 32 53.04 Quite High
Intellectual Impairment 8 50.00 Quite Low
Obsessive-compulsive Disorder 4 46.60 Quite Low
Autism 24 44.92 Quite Low
Cognitive Disorder 12 34.68 Quite Low
Targeted Disruption 40 23.52 Low Low
Phobia 4 8.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently in the literature, no further emphasis was placed on better understanding the effect of oxytocin on ACTH secretion.
oxytocin Regulation (effect) of Localization (secretion) of ACTH
1) Confidence 0.07 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.12 Pain Relevance 0.08
Several studies have demonstrated that, under physiological conditions, the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary corticotrophs is controlled by hypothalamic hormones such as corticotrophin-releasing hormone (CRH) and vasopressin (see reviews in Refs. 51,52) and by oxytocin under stress conditions [53].
oxytocin Regulation (controlled) of Localization (secretion) of ACTH in corticotrophs associated with stress
2) Confidence 0.06 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.36 Pain Relevance 0.04
The ACTH response due to oxytocin can be variable, that is, oxytocin exerts a synergistic or additive effect on ACTH secretion when applied with CRH or vasopressin, respectively [54].
oxytocin Regulation (effect) of Localization (secretion) of ACTH
3) Confidence 0.05 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.07 Pain Relevance 0.03
Several studies have demonstrated that, under physiological conditions, the secretion of adrenocorticotropic hormone (ACTH) by the anterior pituitary corticotrophs is controlled by hypothalamic hormones such as corticotrophin-releasing hormone (CRH) and vasopressin (see reviews in Refs. 51,52) and by oxytocin under stress conditions [53].
oxytocin Regulation (controlled) of Localization (secretion) of adrenocorticotropic hormone in corticotrophs associated with stress
4) Confidence 0.05 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.36 Pain Relevance 0.04

General Comments

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