INT34196

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 1987
Negated 1
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
kidney 3
cerebral cortex 1
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 12 100.00 Very High Very High Very High
agonist 3 99.48 Very High Very High Very High
Clonidine 2 99.00 Very High Very High Very High
antagonist 2 98.28 Very High Very High Very High
cerebral cortex 4 97.00 Very High Very High Very High
Immobilon 9 92.40 High High
withdrawal 1 87.56 High High
narcan 2 86.60 High High
tail-flick 1 85.12 High High
mu opioid receptor 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We examined the effect of chronic opiate treatment on the alpha 2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats.
Spec (examined) Regulation (effect) of alpha 2-adrenergic Spec (examined) Binding (binding) of in kidney associated with antagonist, agonist, opiate, cerebral cortex and clonidine
1) Confidence 0.45 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6317412 Disease Relevance 0 Pain Relevance 0.60
There was no alteration in alpha 2 adrenergic receptor binding.
Neg (no) Regulation (alteration) of alpha 2 adrenergic receptor Binding (binding) of
2) Confidence 0.45 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3031275 Disease Relevance 0 Pain Relevance 0.92
We examined the effect of chronic opiate treatment on the alpha 2-adrenergic receptor binding of both the agonist [3H]clonidine and the antagonist [3H]yohimbine in the cerebral cortex and kidney of rats.
Spec (examined) Regulation (effect) of alpha 2-adrenergic in cerebral cortex Spec (examined) Binding (binding) of in kidney associated with antagonist, agonist, opiate, cerebral cortex and clonidine
3) Confidence 0.15 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6317412 Disease Relevance 0 Pain Relevance 0.60

General Comments

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