INT342016

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.24
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRIO) intracellular (TRIO) cytoplasm (TRIO)
Anatomy Link Frequency
primary motor cortex 1
thalamus 1
TRIO (Homo sapiens)
Pain Link Frequency Relevance Heat
Thalamus 10 98.96 Very High Very High Very High
isoflurane 4 98.04 Very High Very High Very High
halothane 4 97.76 Very High Very High Very High
Versed 6 70.00 Quite High
Hippocampus 17 69.20 Quite High
anesthesia 32 68.72 Quite High
primary somatosensory cortex 2 47.32 Quite Low
amygdala 8 27.80 Quite Low
Anterior cingulate 3 9.52 Low Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Unconsciousness 31 98.70 Very High Very High Very High
Sleep Disorders 26 97.22 Very High Very High Very High
Persistent Vegetative State 18 59.84 Quite High
Epilepsy 45 55.28 Quite High
Convulsion 34 47.76 Quite Low
Arrhythmias 2 Under Development 1 24.64 Low Low
Coma 24 5.00 Very Low Very Low Very Low
Cognitive Disorder 14 5.00 Very Low Very Low Very Low
Syndrome 14 5.00 Very Low Very Low Very Low
Brain Death 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, a PET study (White and Alkire, 2003) employing higher sedation dose with either halothane or isoflurane leading to loss of consciousness demonstrated (using psychophysiological interaction analyses) a decreased functional connectivity between the thalamus and primary motor cortex, and between the thalamus and supplemental motor area.
Negative_regulation (decreased) of functional in thalamus associated with unconsciousness, thalamus, isoflurane, halothane and sleep disorders
1) Confidence 0.02 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC3010745 Disease Relevance 0.59 Pain Relevance 0.30
Because of limited spatial sampling, but also of physiological limitations such as attenuation of the signal in polysynaptic pathways and the recruitment of inhibition, these connectivity figures should be regarded as the lower limit of the true functional connectivity.
Negative_regulation (limit) of functional connectivity
2) Confidence 0.01 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2972750 Disease Relevance 0.06 Pain Relevance 0.03
However, a PET study (White and Alkire, 2003) employing higher sedation dose with either halothane or isoflurane leading to loss of consciousness demonstrated (using psychophysiological interaction analyses) a decreased functional connectivity between the thalamus and primary motor cortex, and between the thalamus and supplemental motor area.
Negative_regulation (decreased) of functional in primary motor cortex associated with unconsciousness, thalamus, isoflurane, halothane and sleep disorders
3) Confidence 0.01 Published 2010 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC3010745 Disease Relevance 0.59 Pain Relevance 0.30

General Comments

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